HIF1A Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use HIF1A-specific vectors and viral particles designed for reliable HIF1A overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including HIF1A CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human HIF1A Gene Overview
| Gene Name | hypoxia inducible factor 1 subunit alpha |
|---|---|
| Gene Symbol | HIF1A |
| Synonyms | HIF1,MOP1,PASD8,HIF-1A,bHLHe78,HIF-1alpha,HIF1-ALPHA,HIF-1-alpha |
| NCBI ID | 3091 |
| Ensembl ID | ENSG00000100644 |
| Uniprot ID | Q16665 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes the alpha subunit of transcription factor hypoxia-inducible factor-1 (HIF-1), which is a heterodimer composed of an alpha and a beta subunit. HIF-1 functions as a master regulator of cellular and systemic homeostatic response to hypoxia by activating transcription of many genes, including those involved in energy metabolism, angiogenesis, apoptosis, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. HIF-1 thus plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Jul 2011]
Human HIF1A Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC123258 | View Product |
| AAV Vector & Virus | Long-term expression | VC123258 | View Product |
| Adenovirus | Transient expression | A123258 | View Product |
| Transient expression | A223258 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG123258 | View Product |
| Gene knockout (non-viral) | PG123258 | View Product | |
| Gene knockout (AAV) | VG123258 | View Product | |
| CRISPR Activation | Gene activation | LA123258 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS223258 | View Product |
| Gene knockdown (AAV) | VS223258 | View Product | |
| ORF Vector | Template DNA | PC123258 | View Product |
Mouse Hif1a Gene Overview
| Gene Name | hypoxia inducible factor 1, alpha subunit |
|---|---|
| Gene Symbol | Hif1a |
| Synonyms | MOP1,bHLHe78,HIF1alpha,HIF1-alpha,HIF-1-alpha |
| NCBI ID | 15251 |
| Ensembl ID | ENSMUSG00000021109 |
| Uniprot ID | Q61221 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes the alpha subunit which, along with the beta subunit, forms a heterodimeric transcription factor that regulates the cellular and developmental response to reduced oxygen tension. The transcription factor has been shown to regulate genes involved in several biological processes, including erythropoiesis and angiogenesis which aid in increased delivery of oxygen to hypoxic regions. The transcription factor also plays a role in the induction of genes involved in cell proliferation and survival, energy metabolism, apoptosis, and glucose and iron metabolism. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2015]
Mouse Hif1a Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC423258 | View Product |
| AAV Vector & Virus | Long-term expression | VC423258 | View Product |
| Adenovirus | Transient expression | A423258 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG423258 | View Product |
| Gene knockout (non-viral) | PG423258 | View Product | |
| Gene knockout (AAV) | VG423258 | View Product | |
| CRISPR Activation | Gene activation | LA423258 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS423258 | View Product |
| Gene knockdown (AAV) | VS423258 | View Product | |
| ORF Vector | Template DNA | PC423258 | View Product |
Rat Gene Overview
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| Gene Symbol | |
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Gene Summary
Rat Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC623258 | View Product |
| AAV Vector & Virus | Long-term expression | VC623258 | View Product |
| Adenovirus | Transient expression | A623258 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG623258 | View Product |
| Gene knockout (non-viral) | PG623258 | View Product | |
| Gene knockout (AAV) | VG623258 | View Product | |
| CRISPR Activation | Gene activation | LA623258 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS623258 | View Product |
| Gene knockdown (AAV) | VS623258 | View Product | |
| ORF Vector | Template DNA | PC623258 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |