HMGA2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use HMGA2-specific vectors and viral particles designed for reliable HMGA2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including HMGA2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human HMGA2 Gene Overview
| Gene Name | high mobility group AT-hook 2 |
|---|---|
| Gene Symbol | HMGA2 |
| Synonyms | BABL,LIPO,SRS5,HMGIC,HMGI-C,STQTL9 |
| NCBI ID | 8091 |
| Ensembl ID | ENSG00000149948 |
| Uniprot ID | P52926 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a protein that belongs to the non-histone chromosomal high mobility group (HMG) protein family. HMG proteins function as architectural factors and are essential components of the enhancesome. This protein contains structural DNA-binding domains and may act as a transcriptional regulating factor. Identification of the deletion, amplification, and rearrangement of this gene that are associated with myxoid liposarcoma suggests a role in adipogenesis and mesenchymal differentiation. A gene knock out study of the mouse counterpart demonstrated that this gene is involved in diet-induced obesity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Human HMGA2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC123495 | View Product |
| AAV Vector & Virus | Long-term expression | VC123495 | View Product |
| Adenovirus | Transient expression | A123495 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG123495 | View Product |
| Gene knockout (non-viral) | PG123495 | View Product | |
| Gene knockout (AAV) | VG123495 | View Product | |
| CRISPR Activation | Gene activation | LA123495 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS123495 | View Product |
| Gene knockdown (AAV) | VS123495 | View Product | |
| ORF Vector | Template DNA | PC123495 | View Product |
Mouse Hmga2 Gene Overview
| Gene Name | high mobility group AT-hook 2 |
|---|---|
| Gene Symbol | Hmga2 |
| Synonyms | pg,Hmgic,pygmy,HMGI-C,9430083A20Rik |
| NCBI ID | 15364 |
| Ensembl ID | ENSMUSG00000056758 |
| Uniprot ID | P52927 |
| Gene Type | Protein coding |
Gene Summary
Enables minor groove of adenine-thymine-rich DNA binding activity. Involved in several processes, including negative regulation of cellular senescence; positive regulation of angiogenesis; and positive regulation of cell proliferation in bone marrow. Acts upstream of or within several processes, including endocrine system development; lung development; and positive regulation of cell population proliferation. Located in male germ cell nucleus and nuclear chromosome. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb long bone; and sensory organ. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; leiomyoma; lipoma; and ovarian cancer. Orthologous to human HMGA2 (high mobility group AT-hook 2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Hmga2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC423495 | View Product |
| AAV Vector & Virus | Long-term expression | VC423495 | View Product |
| Adenovirus | Transient expression | A423495 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG423495 | View Product |
| Gene knockout (non-viral) | PG423495 | View Product | |
| Gene knockout (AAV) | VG423495 | View Product | |
| CRISPR Activation | Gene activation | LA423495 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS423495 | View Product |
| Gene knockdown (AAV) | VS423495 | View Product | |
| ORF Vector | Template DNA | PC423495 | View Product |
Rat Hmga2 Gene Overview
| Gene Name | high mobility group AT-hook 2 |
|---|---|
| Gene Symbol | Hmga2 |
| Synonyms | Hmgic |
| NCBI ID | 84017 |
| Ensembl ID | ENSRNOG00000042460 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Enables enzyme binding activity. Involved in negative regulation of signal transduction and regulation of DNA-templated transcription. Predicted to be located in male germ cell nucleus; nuclear chromosome; and senescence-associated heterochromatin focus. Predicted to be part of SMAD protein complex and protein-DNA complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Silver-Russell syndrome; leiomyoma; lipoma; and ovarian cancer. Orthologous to human HMGA2 (high mobility group AT-hook 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Hmga2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC623495 | View Product |
| AAV Vector & Virus | Long-term expression | VC623495 | View Product |
| Adenovirus | Transient expression | A623495 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG623495 | View Product |
| Gene knockout (non-viral) | PG623495 | View Product | |
| Gene knockout (AAV) | VG623495 | View Product | |
| CRISPR Activation | Gene activation | LA623495 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS623495 | View Product |
| Gene knockdown (AAV) | VS623495 | View Product | |
| ORF Vector | Template DNA | PC623495 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |