HMGB1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use HMGB1-specific vectors and viral particles designed for reliable HMGB1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including HMGB1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human HMGB1 Gene Overview
| Gene Name | high mobility group box 1 |
|---|---|
| Gene Symbol | HMGB1 |
| Synonyms | HMG1,HMG3,HMG-1,SBP-1 |
| NCBI ID | 3146 |
| Ensembl ID | ENSG00000189403 |
| Uniprot ID | P09429 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]
Human HMGB1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC123496 | View Product |
| Stable overexpression | LC223496 | View Product | |
| AAV Vector & Virus | Long-term expression | VC123496 | View Product |
| Long-term expression | VC223496 | View Product | |
| Adenovirus | Transient expression | A123496 | View Product |
| Transient expression | A223496 | View Product | |
| ORF Vector | Template DNA | PC123496 | View Product |
| Template DNA | PC223496 | View Product |
Mouse Hmgb1 Gene Overview
| Gene Name | high mobility group box 1 |
|---|---|
| Gene Symbol | Hmgb1 |
| Synonyms | p30,Hmg1,HMG-1,SBP-1 |
| NCBI ID | 15289 |
| Ensembl ID | ENSMUSG00000066551 |
| Uniprot ID | P63158 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a protein that belongs to the High Mobility Group-box superfamily. The encoded non-histone, nuclear DNA-binding protein regulates transcription, and is involved in organization of DNA. This protein plays a role in several cellular processes, including inflammation, cell differentiation and tumor cell migration. Multiple pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Sep 2015]
Mouse Hmgb1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC423496 | View Product |
| AAV Vector & Virus | Long-term expression | VC423496 | View Product |
| Adenovirus | Transient expression | A423496 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS423496 | View Product |
| Gene knockdown (AAV) | VS423496 | View Product | |
| ORF Vector | Template DNA | PC423496 | View Product |
Rat Hmgb1 Gene Overview
| Gene Name | high mobility group box 1 |
|---|---|
| Gene Symbol | Hmgb1 |
| Synonyms | Hmg1,Ac2-008 |
| NCBI ID | 25459 |
| Ensembl ID | |
| Uniprot ID | P63159 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including DNA binding activity; heparin binding activity; and signaling receptor binding activity. Involved in several processes, including positive regulation of cytokine production; psychomotor behavior; and response to bacterium. Acts upstream of or within several processes, including DNA geometric change; induction of positive chemotaxis; and positive regulation of mesenchymal cell proliferation. Located in cytosol; extracellular space; and membrane raft. Used to study artery disease (multiple); brain infarction; congestive heart failure; high grade glioma; and sciatic neuropathy. Biomarker of several diseases, including alcohol use disorder; colon adenocarcinoma; hydrocephalus; middle cerebral artery infarction; and obstructive jaundice. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis. Orthologous to human HMGB1 (high mobility group box 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Hmgb1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC623496 | View Product |
| AAV Vector & Virus | Long-term expression | VC623496 | View Product |
| Adenovirus | Transient expression | A623496 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS623496 | View Product |
| Gene knockdown (AAV) | VS623496 | View Product | |
| ORF Vector | Template DNA | PC623496 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |