HMGCR Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use HMGCR-specific vectors and viral particles designed for reliable HMGCR overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including HMGCR CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human HMGCR Gene Overview
| Gene Name | 3-hydroxy-3-methylglutaryl-CoA reductase |
|---|---|
| Gene Symbol | HMGCR |
| Synonyms | MYPLG,LDLCQ3,LGMDR28 |
| NCBI ID | 3156 |
| Ensembl ID | ENSG00000113161 |
| Uniprot ID | P04035 |
| Gene Type | Protein coding |
Gene Summary
HMG-CoA reductase is the rate-limiting enzyme for cholesterol synthesis and is regulated via a negative feedback mechanism mediated by sterols and non-sterol metabolites derived from mevalonate, the product of the reaction catalyzed by reductase. Normally in mammalian cells this enzyme is suppressed by cholesterol derived from the internalization and degradation of low density lipoprotein (LDL) via the LDL receptor. Competitive inhibitors of the reductase induce the expression of LDL receptors in the liver, which in turn increases the catabolism of plasma LDL and lowers the plasma concentration of cholesterol, an important determinant of atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Human HMGCR Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC123583 | View Product |
| AAV Vector & Virus | Long-term expression | VC123583 | View Product |
| Adenovirus | Transient expression | A123583 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG123583 | View Product |
| Gene knockout (non-viral) | PG123583 | View Product | |
| Gene knockout (AAV) | VG123583 | View Product | |
| CRISPR Activation | Gene activation | LA123583 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS123583 | View Product |
| Gene knockdown (AAV) | VS123583 | View Product | |
| ORF Vector | Template DNA | PC123583 | View Product |
Mouse Hmgcr Gene Overview
| Gene Name | 3-hydroxy-3-methylglutaryl-Coenzyme A reductase |
|---|---|
| Gene Symbol | Hmgcr |
| Synonyms | Red,HMG-CoAR |
| NCBI ID | 15357 |
| Ensembl ID | ENSMUSG00000021670 |
| Uniprot ID | Q01237 |
| Gene Type | Protein coding |
Gene Summary
Enables GTPase regulator activity and hydroxymethylglutaryl-CoA reductase (NADPH) activity. Involved in negative regulation of amyloid-beta clearance; negative regulation of protein catabolic process; and negative regulation of protein secretion. Acts upstream of or within several processes, including long-term synaptic potentiation; regulation of MAPK cascade; and visual learning. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane and peroxisomal membrane. Is expressed in several structures, including autopod; branchial arch; central nervous system; ganglia; and heart valve. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; coronary artery disease (multiple); diabetes mellitus (multiple); muscular disease (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Hmgcr Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC423583 | View Product |
| AAV Vector & Virus | Long-term expression | VC423583 | View Product |
| Adenovirus | Transient expression | A423583 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG423583 | View Product |
| Gene knockout (non-viral) | PG423583 | View Product | |
| Gene knockout (AAV) | VG423583 | View Product | |
| CRISPR Activation | Gene activation | LA423583 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS423583 | View Product |
| Gene knockdown (AAV) | VS423583 | View Product | |
| ORF Vector | Template DNA | PC423583 | View Product |
Rat Hmgcr Gene Overview
| Gene Name | 3-hydroxy-3-methylglutaryl-CoA reductase |
|---|---|
| Gene Symbol | Hmgcr |
| Synonyms | 3H3M |
| NCBI ID | 25675 |
| Ensembl ID | ENSRNOG00000016122 |
| Uniprot ID | P51639 |
| Gene Type | Protein coding |
Gene Summary
Enables identical protein binding activity and protein phosphatase 2A binding activity. Involved in several processes, including cholesterol homeostasis; positive regulation of MAPK cascade; and regulation of striated muscle cell apoptotic process. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane and peroxisomal membrane. Used to study Wilson disease; drug-induced hepatitis; end stage renal disease; pulmonary hypertension; and type 2 diabetes mellitus. Biomarker of chronic kidney disease; end stage renal disease; metabolic dysfunction-associated steatotic liver disease; and premature menopause. Human ortholog(s) of this gene implicated in several diseases, including attention deficit hyperactivity disorder; coronary artery disease (multiple); diabetes mellitus (multiple); muscular disease (multiple); and neurodegenerative disease (multiple). Orthologous to human HMGCR (3-hydroxy-3-methylglutaryl-CoA reductase). [provided by Alliance of Genome Resources, Jul 2025]
Rat Hmgcr Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC623583 | View Product |
| AAV Vector & Virus | Long-term expression | VC623583 | View Product |
| Adenovirus | Transient expression | A623583 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG623583 | View Product |
| Gene knockout (non-viral) | PG623583 | View Product | |
| Gene knockout (AAV) | VG623583 | View Product | |
| CRISPR Activation | Gene activation | LA623583 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS623583 | View Product |
| Gene knockdown (AAV) | VS623583 | View Product | |
| ORF Vector | Template DNA | PC623583 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |