HNF4A Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use HNF4A-specific vectors and viral particles designed for reliable HNF4A overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including HNF4A CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human HNF4A Gene Overview
| Gene Name | hepatocyte nuclear factor 4 alpha |
|---|---|
| Gene Symbol | HNF4A |
| Synonyms | TCF,HNF4,MODY,FRTS4,MODY1,NR2A1,TCF14,HNF4a7,HNF4a8,HNF4a9,NR2A21,TCF-14,HNF4alpha |
| NCBI ID | 3172 |
| Ensembl ID | ENSG00000101076 |
| Uniprot ID | P41235 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a nuclear transcription factor which binds DNA as a homodimer. The encoded protein controls the expression of several genes, including hepatocyte nuclear factor 1 alpha, a transcription factor which regulates the expression of several hepatic genes. This gene may play a role in development of the liver, kidney, and intestines. Mutations in this gene have been associated with monogenic autosomal dominant non-insulin-dependent diabetes mellitus type I. Alternative splicing of this gene results in multiple transcript variants encoding several different isoforms. [provided by RefSeq, Apr 2012]
Human HNF4A Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC123695 | View Product |
| AAV Vector & Virus | Long-term expression | VC123695 | View Product |
| Adenovirus | Transient expression | A123695 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG123695 | View Product |
| Gene knockout (non-viral) | PG123695 | View Product | |
| Gene knockout (AAV) | VG123695 | View Product | |
| CRISPR Activation | Gene activation | LA123695 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS123695 | View Product |
| Gene knockdown (AAV) | VS123695 | View Product | |
| ORF Vector | Template DNA | PC123695 | View Product |
Mouse Hnf4a Gene Overview
| Gene Name | hepatic nuclear factor 4, alpha |
|---|---|
| Gene Symbol | Hnf4a |
| Synonyms | Hnf4,HNF-4,MODY1,Nr2a1,Tcf14,TCF-14,Hnf4alpha |
| NCBI ID | 15378 |
| Ensembl ID | ENSMUSG00000017950 |
| Uniprot ID | P49698 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a transcription factor involved in the development of the pancreas, liver, kidney, and intestines. The encoded protein also functions to maintain glucose homeostasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Mouse Hnf4a Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC423695 | View Product |
| AAV Vector & Virus | Long-term expression | VC423695 | View Product |
| Adenovirus | Transient expression | A423695 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG423695 | View Product |
| Gene knockout (non-viral) | PG423695 | View Product | |
| Gene knockout (AAV) | VG423695 | View Product | |
| CRISPR Activation | Gene activation | LA423695 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS423695 | View Product |
| Gene knockdown (AAV) | VS423695 | View Product | |
| ORF Vector | Template DNA | PC423695 | View Product |
Rat Hnf4a Gene Overview
| Gene Name | hepatocyte nuclear factor 4, alpha |
|---|---|
| Gene Symbol | Hnf4a |
| Synonyms | Hnf4,Hnf4alpha |
| NCBI ID | 25735 |
| Ensembl ID | ENSRNOG00000008895 |
| Uniprot ID | P22449 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; anion binding activity; and long-chain fatty acyl-CoA hydrolase activity. Involved in several processes, including hepatocyte differentiation; negative regulation of non-membrane spanning protein tyrosine kinase activity; and positive regulation of biosynthetic process. Located in nucleus. Biomarker of hepatocellular carcinoma and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha). [provided by Alliance of Genome Resources, Apr 2025]
Rat Hnf4a Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC623695 | View Product |
| AAV Vector & Virus | Long-term expression | VC623695 | View Product |
| Adenovirus | Transient expression | A623695 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG623695 | View Product |
| Gene knockout (non-viral) | PG623695 | View Product | |
| Gene knockout (AAV) | VG623695 | View Product | |
| CRISPR Activation | Gene activation | LA623695 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS623695 | View Product |
| Gene knockdown (AAV) | VS623695 | View Product | |
| ORF Vector | Template DNA | PC623695 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |