HOTAIR Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use HOTAIR-specific vectors and viral particles designed for reliable HOTAIR overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including HOTAIR CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human HOTAIR Gene Overview
| Gene Name | HOX transcript antisense RNA |
|---|---|
| Gene Symbol | HOTAIR |
| Synonyms | HOXAS,HOXC-AS4,HOXC11-AS1,NCRNA00072 |
| NCBI ID | 100124700 |
| Ensembl ID | ENSG00000228630 |
| Uniprot ID | |
| Gene Type | ncRNA |
Gene Summary
This gene is located within the Homeobox C (HOXC) gene cluster on chromosome 12 and is co-expressed with the HOXC genes. It functions through an RNA product, which binds lysine specific demethylase 1 (LSD1) and Polycomb repressive complex 2 (PRC2), and serves as a scaffold to assemble these regulators at the HOXD gene cluster, thereby promoting epigenetic repression of HOXD. This gene is highly expressed in multiple tumors. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Feb 2019]
Human HOTAIR Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC123793 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG123793 | View Product |
| Gene knockout (non-viral) | PG123793 | View Product | |
| Gene knockout (AAV) | VG123793 | View Product | |
| CRISPR Activation | Gene activation | LA123793 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS123793 | View Product |
| Gene knockdown (AAV) | VS123793 | View Product | |
| ORF Vector | Template DNA | PC123793 | View Product |
Mouse Hotair Gene Overview
| Gene Name | HOX transcript antisense RNA (non-protein coding) |
|---|---|
| Gene Symbol | Hotair |
| Synonyms | Gm16258 |
| NCBI ID | 100503872 |
| Ensembl ID | ENSMUSG00000086903 |
| Uniprot ID | |
| Gene Type | ncRNA |
Gene Summary
A long non-coding RNA is transcribed from this gene. The same as human gene, this gene is located between Hoxc11 and Hoxc12 genes in the Hoxc gene cluster. This gene is not conserved in sequence, and differently from the human gene, its absence has little effect on transcription efficiency of the Hoxd gene cluster. [provided by RefSeq, Apr 2012]
Mouse Hotair Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|
Rat Gene Overview
| Gene Name | |
|---|---|
| Gene Symbol | |
| Synonyms | |
| NCBI ID | |
| Ensembl ID | |
| Uniprot ID | |
| Gene Type |
Gene Summary
Rat Related Products
| Product Type | Key Applications | Cat. No. | Product |
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Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |