IDO1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use IDO1-specific vectors and viral particles designed for reliable IDO1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including IDO1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human IDO1 Gene Overview
| Gene Name | indoleamine 2,3-dioxygenase 1 |
|---|---|
| Gene Symbol | IDO1 |
| Synonyms | IDO,INDO,IDO-1 |
| NCBI ID | 3620 |
| Ensembl ID | ENSG00000131203 |
| Uniprot ID | P14902 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]
Human IDO1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC124196 | View Product |
| AAV Vector & Virus | Long-term expression | VC124196 | View Product |
| Adenovirus | Transient expression | A124196 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG124196 | View Product |
| Gene knockout (non-viral) | PG124196 | View Product | |
| Gene knockout (AAV) | VG124196 | View Product | |
| CRISPR Activation | Gene activation | LA124196 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS124196 | View Product |
| Gene knockdown (AAV) | VS124196 | View Product | |
| ORF Vector | Template DNA | PC124196 | View Product |
Mouse Ido1 Gene Overview
| Gene Name | indoleamine 2,3-dioxygenase 1 |
|---|---|
| Gene Symbol | Ido1 |
| Synonyms | Ido,Indo |
| NCBI ID | 15930 |
| Ensembl ID | ENSMUSG00000031551 |
| Uniprot ID | P28776 |
| Gene Type | Protein coding |
Gene Summary
Enables tryptophan 2,3-dioxygenase activity. Involved in quinolinate biosynthetic process. Acts upstream of or within several processes, including carboxylic acid metabolic process; regulation of apoptotic process; and regulation of cytokine production. Located in smooth muscle contractile fiber and stereocilium bundle. Is expressed in cerebral cortex; corpus striatum; embryo; extraembryonic component; and hippocampus. Used to study pre-eclampsia. Orthologous to human IDO1 (indoleamine 2,3-dioxygenase 1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Ido1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC424196 | View Product |
| AAV Vector & Virus | Long-term expression | VC424196 | View Product |
| Adenovirus | Transient expression | A424196 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG424196 | View Product |
| Gene knockout (non-viral) | PG424196 | View Product | |
| Gene knockout (AAV) | VG424196 | View Product | |
| CRISPR Activation | Gene activation | LA424196 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS424196 | View Product |
| Gene knockdown (AAV) | VS424196 | View Product | |
| ORF Vector | Template DNA | PC424196 | View Product |
Rat Ido1 Gene Overview
| Gene Name | indoleamine 2,3-dioxygenase 1 |
|---|---|
| Gene Symbol | Ido1 |
| Synonyms | Ido,Indo |
| NCBI ID | 66029 |
| Ensembl ID | ENSRNOG00000031189 |
| Uniprot ID | Q9ERD9 |
| Gene Type | Protein coding |
Gene Summary
Enables amino acid binding activity; indoleamine 2,3-dioxygenase activity; and oxygen binding activity. Involved in L-tryptophan catabolic process to kynurenine. Predicted to be located in smooth muscle contractile fiber and stereocilium bundle. Predicted to be active in cytoplasm. Orthologous to human IDO1 (indoleamine 2,3-dioxygenase 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Ido1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC624196 | View Product |
| AAV Vector & Virus | Long-term expression | VC624196 | View Product |
| Adenovirus | Transient expression | A624196 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG624196 | View Product |
| Gene knockout (non-viral) | PG624196 | View Product | |
| Gene knockout (AAV) | VG624196 | View Product | |
| CRISPR Activation | Gene activation | LA624196 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS624196 | View Product |
| Gene knockdown (AAV) | VS624196 | View Product | |
| ORF Vector | Template DNA | PC624196 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |