IFIH1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use IFIH1-specific vectors and viral particles designed for reliable IFIH1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including IFIH1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human IFIH1 Gene Overview
| Gene Name | interferon induced with helicase C domain 1 |
|---|---|
| Gene Symbol | IFIH1 |
| Synonyms | AGS7,Hlcd,MDA5,IMD95,MDA-5,RLR-2,IDDM19,SGMRT1 |
| NCBI ID | 64135 |
| Ensembl ID | ENSG00000115267 |
| Uniprot ID | Q9BYX4 |
| Gene Type | Protein coding |
Gene Summary
IFIH1 encodes MDA5 which is an intracellular sensor of viral RNA that triggers the innate immune response. Sensing RNA length and secondary structure, MDA5 binds dsRNA oligonucleotides with a modified DExD/H-box helicase core and a C-terminal domain, thus leading to a proinflammatory response that includes interferons. It has been shown that Coronaviruses (CoVs) as well as various other virus families, are capable of evading the MDA5-dependent interferon response, thus impeding the activation of the innate immune response to infection. MDA5 has also been shown to play an important role in enhancing natural killer cell function in malaria infection. In addition to its protective role in antiviral responses, MDA5 has been implicated in autoimmune and autoinflammatory diseases such as type 1 diabetes, systemic lupus erythematosus, and Aicardi-Goutieres syndrome[provided by RefSeq, Jul 2020]
Human IFIH1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC124224 | View Product |
| AAV Vector & Virus | Long-term expression | VC124224 | View Product |
| Adenovirus | Transient expression | A124224 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG124224 | View Product |
| Gene knockout (non-viral) | PG124224 | View Product | |
| Gene knockout (AAV) | VG124224 | View Product | |
| CRISPR Activation | Gene activation | LA124224 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS124224 | View Product |
| Gene knockdown (AAV) | VS124224 | View Product | |
| ORF Vector | Template DNA | PC124224 | View Product |
Mouse Ifih1 Gene Overview
| Gene Name | interferon induced with helicase C domain 1 |
|---|---|
| Gene Symbol | Ifih1 |
| Synonyms | Hlcd,MDA5,RLR-2,Helicard,9130009C22Rik |
| NCBI ID | 71586 |
| Ensembl ID | ENSMUSG00000026896 |
| Uniprot ID | Q8R5F7 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including ATP hydrolysis activity; RNA binding activity; and zinc ion binding activity. Involved in innate immune response and response to virus. Acts upstream of or within antiviral innate immune response; protein complex oligomerization; and type I interferon-mediated signaling pathway. Located in cytoplasm. Is expressed in brain and embryo. Used to study Aicardi-Goutieres syndrome and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome and immunodeficiency 95. Orthologous to human IFIH1 (interferon induced with helicase C domain 1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Ifih1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC424224 | View Product |
| Stable overexpression | LC524224 | View Product | |
| AAV Vector & Virus | Long-term expression | VC424224 | View Product |
| Long-term expression | VC524224 | View Product | |
| Adenovirus | Transient expression | A424224 | View Product |
| Transient expression | A524224 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG424224 | View Product |
| Gene knockout (non-viral) | PG424224 | View Product | |
| Gene knockout (AAV) | VG424224 | View Product | |
| CRISPR Activation | Gene activation | LA424224 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS424224 | View Product |
| Gene knockdown (AAV) | VS424224 | View Product | |
| ORF Vector | Template DNA | PC424224 | View Product |
| Template DNA | PC524224 | View Product |
Rat Ifih1 Gene Overview
| Gene Name | interferon induced with helicase C domain 1 |
|---|---|
| Gene Symbol | Ifih1 |
| Synonyms | RGD1560496 |
| NCBI ID | 499801 |
| Ensembl ID | ENSRNOG00000006227 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including ATP hydrolysis activity; RNA binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including MDA-5 signaling pathway; antiviral innate immune response; and positive regulation of cytokine production. Predicted to act upstream of or within protein complex oligomerization and type I interferon-mediated signaling pathway. Predicted to be located in mitochondrion. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in Aicardi-Goutieres syndrome and immunodeficiency 95. Orthologous to human IFIH1 (interferon induced with helicase C domain 1). [provided by Alliance of Genome Resources, Apr 2025]
Rat Ifih1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC624224 | View Product |
| AAV Vector & Virus | Long-term expression | VC624224 | View Product |
| Adenovirus | Transient expression | A624224 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG624224 | View Product |
| Gene knockout (non-viral) | PG624224 | View Product | |
| Gene knockout (AAV) | VG624224 | View Product | |
| CRISPR Activation | Gene activation | LA624224 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS624224 | View Product |
| Gene knockdown (AAV) | VS624224 | View Product | |
| ORF Vector | Template DNA | PC624224 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |