IGF1R Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use IGF1R-specific vectors and viral particles designed for reliable IGF1R overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including IGF1R CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human IGF1R Gene Overview
| Gene Name | insulin like growth factor 1 receptor |
|---|---|
| Gene Symbol | IGF1R |
| Synonyms | IGFR,CD221,IGFIR,JTK13 |
| NCBI ID | 3480 |
| Ensembl ID | ENSG00000140443 |
| Uniprot ID | P08069 |
| Gene Type | Protein coding |
Gene Summary
This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]
Human IGF1R Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC124313 | View Product |
| Adenovirus | Transient expression | A124313 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG124313 | View Product |
| Gene knockout (non-viral) | PG124313 | View Product | |
| Gene knockout (AAV) | VG124313 | View Product | |
| CRISPR Activation | Gene activation | LA124313 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS124313 | View Product |
| Gene knockdown (AAV) | VS124313 | View Product | |
| ORF Vector | Template DNA | PC124313 | View Product |
Mouse Igf1r Gene Overview
| Gene Name | insulin-like growth factor I receptor |
|---|---|
| Gene Symbol | Igf1r |
| Synonyms | hyft,CD221,IGF-1R,D930020L01,A330103N21Rik |
| NCBI ID | 16001 |
| Ensembl ID | ENSMUSG00000005533 |
| Uniprot ID | Q60751 |
| Gene Type | Protein coding |
Gene Summary
Enables insulin-like growth factor binding activity and insulin-like growth factor receptor activity. Involved in several processes, including adrenal gland development; insulin-like growth factor receptor signaling pathway; and positive regulation of metabolic process. Acts upstream of or within several processes, including exocrine pancreas development; peptidyl-tyrosine autophosphorylation; and regulation of intracellular signal transduction. Located in T-tubule. Is active in glutamatergic synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; limb; and lung. Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and neurodegenerative disease (multiple). Orthologous to human IGF1R (insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Igf1r Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC424313 | View Product |
| Adenovirus | Transient expression | A424313 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG431807 | View Product |
| Gene knockout (Lentiviral) | LG459561 | View Product | |
| Gene knockout (non-viral) | PG431807 | View Product | |
| Gene knockout (non-viral) | PG459561 | View Product | |
| Gene knockout (AAV) | VG431807 | View Product | |
| Gene knockout (AAV) | VG459561 | View Product | |
| CRISPR Activation | Gene activation | LA431807 | View Product |
| Gene activation | LA459561 | View Product | |
| siRNA Tools | Gene knockdown (Lentiviral) | LS431807 | View Product |
| Gene knockdown (AAV) | VS431807 | View Product | |
| Gene knockdown (AAV) | VS459561 | View Product | |
| ORF Vector | Template DNA | PC424313 | View Product |
Rat Igf1r Gene Overview
| Gene Name | insulin-like growth factor 1 receptor |
|---|---|
| Gene Symbol | Igf1r |
| Synonyms | Igfr1,JTK13,IGFIRC,IGF-1 receptor |
| NCBI ID | 25718 |
| Ensembl ID | ENSRNOG00000014187 |
| Uniprot ID | P24062 |
| Gene Type | Protein coding |
Gene Summary
Enables G-protein alpha-subunit binding activity; insulin receptor substrate binding activity; and insulin-like growth factor receptor activity. Involved in several processes, including cellular response to ketone; cellular response to peptide hormone stimulus; and negative regulation of apoptotic process. Located in several cellular components, including T-tubule; caveola; and neuronal cell body. Used to study Alzheimer's disease; Parkinson's disease; and prostate adenocarcinoma. Biomarker of several diseases, including alcoholic neuropathy; artery disease (multiple); carcinoma (multiple); diabetes mellitus (multiple); and neurodegenerative disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including IgA glomerulonephritis; dementia (multiple); kidney cancer (multiple); liver disease (multiple); and toxic encephalopathy. Orthologous to human IGF1R (insulin like growth factor 1 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Rat Igf1r Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC624313 | View Product |
| Adenovirus | Transient expression | A624313 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG624313 | View Product |
| Gene knockout (non-viral) | PG624313 | View Product | |
| Gene knockout (AAV) | VG624313 | View Product | |
| CRISPR Activation | Gene activation | LA624313 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS624313 | View Product |
| Gene knockdown (AAV) | VS624313 | View Product | |
| ORF Vector | Template DNA | PC624313 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |