IGF2R Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use IGF2R-specific vectors and viral particles designed for reliable IGF2R overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including IGF2R CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human IGF2R Gene Overview
| Gene Name | insulin like growth factor 2 receptor |
|---|---|
| Gene Symbol | IGF2R |
| Synonyms | MPR1,MPRI,CD222,CIMPR,M6P-R,MPR300,CI-M6PR,MPR 300,M6P/IGF2R |
| NCBI ID | 3482 |
| Ensembl ID | ENSG00000197081 |
| Uniprot ID | P11717 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a receptor for both insulin-like growth factor 2 and mannose 6-phosphate. The binding sites for each ligand are located on different segments of the protein. This receptor has various functions, including in the intracellular trafficking of lysosomal enzymes, the activation of transforming growth factor beta, and the degradation of insulin-like growth factor 2. Mutation or loss of heterozygosity of this gene has been association with risk of hepatocellular carcinoma. The orthologous mouse gene is imprinted and shows exclusive expression from the maternal allele; however, imprinting of the human gene may be polymorphic, as only a minority of individuals showed biased expression from the maternal allele (PMID:8267611). [provided by RefSeq, Nov 2015]
Human IGF2R Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG124319 | View Product |
| Gene knockout (non-viral) | PG124319 | View Product | |
| Gene knockout (AAV) | VG124319 | View Product | |
| CRISPR Activation | Gene activation | LA124319 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS124319 | View Product |
| Gene knockdown (AAV) | VS124319 | View Product | |
| ORF Vector | Template DNA | PC124319 | View Product |
Mouse Igf2r Gene Overview
| Gene Name | insulin-like growth factor 2 receptor |
|---|---|
| Gene Symbol | Igf2r |
| Synonyms | CD222,CI-MPR,Mpr300,M6P/IGF2R |
| NCBI ID | 16004 |
| Ensembl ID | ENSMUSG00000023830 |
| Uniprot ID | Q07113 |
| Gene Type | Protein coding |
Gene Summary
Enables D-mannose binding activity and insulin-like growth factor binding activity. Predicted to be involved in several processes, including liver development; positive regulation by host of viral process; and response to retinoic acid. Located in membrane and nuclear envelope lumen. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; early conceptus; and genitourinary system. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); hepatocellular carcinoma; in situ carcinoma (multiple); and nephroblastoma. Orthologous to human IGF2R (insulin like growth factor 2 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Igf2r Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG424319 | View Product |
| Gene knockout (non-viral) | PG424319 | View Product | |
| Gene knockout (AAV) | VG424319 | View Product | |
| CRISPR Activation | Gene activation | LA424319 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS424319 | View Product |
| Gene knockdown (AAV) | VS424319 | View Product | |
| ORF Vector | Template DNA | PC424319 | View Product |
Rat Igf2r Gene Overview
| Gene Name | insulin-like growth factor 2 receptor |
|---|---|
| Gene Symbol | Igf2r |
| Synonyms | Igfr2,IGF-IIR |
| NCBI ID | 25151 |
| Ensembl ID | ENSRNOG00000014997 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including G-protein alpha-subunit binding activity; insulin-like growth factor II binding activity; and retinoic acid binding activity. Involved in several processes, including animal organ regeneration; response to retinoic acid; and response to tetrachloromethane. Located in several cellular components, including late endosome; perinuclear region of cytoplasm; and trans-Golgi network. Part of clathrin coat. Used to study lung adenocarcinoma. Biomarker of amyotrophic lateral sclerosis. Human ortholog(s) of this gene implicated in diabetes mellitus (multiple); hepatocellular carcinoma; in situ carcinoma (multiple); and nephroblastoma. Orthologous to human IGF2R (insulin like growth factor 2 receptor). [provided by Alliance of Genome Resources, Jul 2025]
Rat Igf2r Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG624319 | View Product |
| Gene knockout (non-viral) | PG624319 | View Product | |
| Gene knockout (AAV) | VG624319 | View Product | |
| CRISPR Activation | Gene activation | LA624319 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS624319 | View Product |
| Gene knockdown (AAV) | VS624319 | View Product | |
| ORF Vector | Template DNA | PC624319 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |