IKBKB Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use IKBKB-specific vectors and viral particles designed for reliable IKBKB overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including IKBKB CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human IKBKB Gene Overview
| Gene Name | inhibitor of nuclear factor kappa B kinase subunit beta |
|---|---|
| Gene Symbol | IKBKB |
| Synonyms | IKK2,IKKB,IKK-2,IMD15,IMD15A,IMD15B,NFKBIKB,IKK-beta |
| NCBI ID | 3551 |
| Ensembl ID | ENSG00000104365 |
| Uniprot ID | O14920 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene phosphorylates the inhibitor in the inhibitor/NF-kappa-B complex, causing dissociation of the inhibitor and activation of NF-kappa-B. The encoded protein itself is found in a complex of proteins. Several transcript variants, some protein-coding and some not, have been found for this gene. [provided by RefSeq, Sep 2011]
Human IKBKB Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| AAV Vector & Virus | Long-term expression | VC124797 | View Product |
| Adenovirus | Transient expression | A124797 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG124797 | View Product |
| Gene knockout (non-viral) | PG124797 | View Product | |
| Gene knockout (AAV) | VG124797 | View Product | |
| CRISPR Activation | Gene activation | LA124797 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS124797 | View Product |
| Gene knockdown (AAV) | VS124797 | View Product | |
| ORF Vector | Template DNA | PC124797 | View Product |
Mouse Ikbkb Gene Overview
| Gene Name | inhibitor of kappaB kinase beta |
|---|---|
| Gene Symbol | Ikbkb |
| Synonyms | IKK2,IKK-2,IKK-B,IKK[b],IKKbeta,NFKBIKB,IKK-beta |
| NCBI ID | 16150 |
| Ensembl ID | ENSMUSG00000031537 |
| Uniprot ID | O88351 |
| Gene Type | Protein coding |
Gene Summary
Enables IkappaB kinase activity and protein phosphatase binding activity. Involved in canonical NF-kappaB signal transduction; cell surface receptor signaling pathway; and peptidyl-serine phosphorylation. Acts upstream of or within several processes, including B cell homeostasis; negative regulation of canonical NF-kappaB signal transduction; and positive regulation of monoatomic ion transport. Located in cytoplasmic side of plasma membrane. Part of CD40 receptor complex and IkappaB kinase complex. Is expressed in several structures, including cerebral cortex; genitourinary system; heart; and musculature. Used to study immunodeficiency 15A. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; combined immunodeficiency (multiple); liver cancer; prostate cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Ikbkb Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC424797 | View Product |
| Stable overexpression | LC524797 | View Product | |
| AAV Vector & Virus | Long-term expression | VC424797 | View Product |
| Long-term expression | VC524797 | View Product | |
| Adenovirus | Transient expression | A424797 | View Product |
| Transient expression | A524797 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG424797 | View Product |
| Gene knockout (non-viral) | PG424797 | View Product | |
| Gene knockout (AAV) | VG424797 | View Product | |
| CRISPR Activation | Gene activation | LA424797 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS424797 | View Product |
| Gene knockdown (AAV) | VS424797 | View Product | |
| ORF Vector | Template DNA | PC424797 | View Product |
| Template DNA | PC524797 | View Product |
Rat Ikbkb Gene Overview
| Gene Name | inhibitor of nuclear factor kappa B kinase subunit beta |
|---|---|
| Gene Symbol | Ikbkb |
| Synonyms | IKK2,AIM-1 |
| NCBI ID | 84351 |
| Ensembl ID | ENSRNOG00000019073 |
| Uniprot ID | Q9QY78 |
| Gene Type | Protein coding |
Gene Summary
Enables ATP binding activity. Contributes to IkappaB kinase activity. Involved in several processes, including positive regulation of NF-kappaB transcription factor activity; response to cholecystokinin; and response to lipopolysaccharide. Part of IkappaB kinase complex. Used to study muscular atrophy and pneumonia. Biomarker of Alzheimer's disease; colitis; colon cancer; hypertension; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in several diseases, including breast cancer; combined immunodeficiency (multiple); liver cancer; prostate cancer (multiple); and type 2 diabetes mellitus. Orthologous to human IKBKB (inhibitor of nuclear factor kappa B kinase subunit beta). [provided by Alliance of Genome Resources, Jul 2025]
Rat Ikbkb Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC624797 | View Product |
| AAV Vector & Virus | Long-term expression | VC624797 | View Product |
| Adenovirus | Transient expression | A624797 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG624797 | View Product |
| Gene knockout (non-viral) | PG624797 | View Product | |
| Gene knockout (AAV) | VG624797 | View Product | |
| CRISPR Activation | Gene activation | LA624797 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS624797 | View Product |
| Gene knockdown (AAV) | VS624797 | View Product | |
| ORF Vector | Template DNA | PC624797 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |