IL10 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use IL10-specific vectors and viral particles designed for reliable IL10 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including IL10 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human IL10 Gene Overview
| Gene Name | interleukin 10 |
|---|---|
| Gene Symbol | IL10 |
| Synonyms | CSIF,TGIF,GVHDS,IL-10,IL10A |
| NCBI ID | 3586 |
| Ensembl ID | ENSG00000136634 |
| Uniprot ID | P22301 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]
Human IL10 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC124807 | View Product |
| AAV Vector & Virus | Long-term expression | VC124807 | View Product |
| Adenovirus | Transient expression | A124807 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG124807 | View Product |
| Gene knockout (non-viral) | PG124807 | View Product | |
| Gene knockout (AAV) | VG124807 | View Product | |
| CRISPR Activation | Gene activation | LA124807 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS124807 | View Product |
| Gene knockdown (AAV) | VS124807 | View Product | |
| ORF Vector | Template DNA | PC124807 | View Product |
Mouse Il10 Gene Overview
| Gene Name | interleukin 10 |
|---|---|
| Gene Symbol | Il10 |
| Synonyms | CSIF,If2a,Il-10 |
| NCBI ID | 16153 |
| Ensembl ID | ENSMUSG00000016529 |
| Uniprot ID | P18893 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes an anti-inflammatory cytokine that is a member of the class-2 cytokine family. The encoded protein is secreted by cells of both the innate and adaptive immune systems and is crucial for limiting the immune response to a broad range of pathogens. It also has been shown to suppress autoimmune responses. This protein mediates it's immunosuppressive signal through a specific interleukin 10 receptor complex. Aberrant functioning of this gene is associated with numerous immune disorders including graft-versus-host disease, and increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, Sep 2015]
Mouse Il10 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC424807 | View Product |
| AAV Vector & Virus | Long-term expression | VC424807 | View Product |
| Adenovirus | Transient expression | A424807 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG424807 | View Product |
| Gene knockout (non-viral) | PG424807 | View Product | |
| Gene knockout (AAV) | VG424807 | View Product | |
| CRISPR Activation | Gene activation | LA424807 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS424807 | View Product |
| Gene knockdown (AAV) | VS424807 | View Product | |
| ORF Vector | Template DNA | PC424807 | View Product |
Rat Il10 Gene Overview
| Gene Name | interleukin 10 |
|---|---|
| Gene Symbol | Il10 |
| Synonyms | If2a,IL10X |
| NCBI ID | 25325 |
| Ensembl ID | ENSRNOG00000004647 |
| Uniprot ID | P29456 |
| Gene Type | Protein coding |
Gene Summary
Enables interleukin-10 receptor binding activity. Involved in several processes, including cellular response to estradiol stimulus; liver regeneration; and negative regulation of biosynthetic process. Located in extracellular space. Used to study several diseases, including lung disease (multiple); perinatal necrotizing enterocolitis; sciatic neuropathy; toxic encephalopathy; and transient cerebral ischemia. Biomarker of several diseases, including alcohol use disorder; artery disease (multiple); decubitus ulcer; liver disease (multiple); and lung disease (multiple). Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); eye disease (multiple); gastrointestinal system cancer (multiple); and hematologic cancer (multiple). Orthologous to human IL10 (interleukin 10). [provided by Alliance of Genome Resources, Apr 2025]
Rat Il10 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC624807 | View Product |
| AAV Vector & Virus | Long-term expression | VC624807 | View Product |
| Adenovirus | Transient expression | A624807 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG624807 | View Product |
| Gene knockout (non-viral) | PG624807 | View Product | |
| Gene knockout (AAV) | VG624807 | View Product | |
| CRISPR Activation | Gene activation | LA624807 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS624807 | View Product |
| Gene knockdown (AAV) | VS624807 | View Product | |
| ORF Vector | Template DNA | PC624807 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |