IMPDH2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use IMPDH2-specific vectors and viral particles designed for reliable IMPDH2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including IMPDH2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human IMPDH2 Gene Overview
| Gene Name | inosine monophosphate dehydrogenase 2 |
|---|---|
| Gene Symbol | IMPDH2 |
| Synonyms | IMPD2,IMPDH-II |
| NCBI ID | 3615 |
| Ensembl ID | ENSG00000178035 |
| Uniprot ID | P12268 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes the rate-limiting enzyme in the de novo guanine nucleotide biosynthesis. It is thus involved in maintaining cellular guanine deoxy- and ribonucleotide pools needed for DNA and RNA synthesis. The encoded protein catalyzes the NAD-dependent oxidation of inosine-5'-monophosphate into xanthine-5'-monophosphate, which is then converted into guanosine-5'-monophosphate. This gene is up-regulated in some neoplasms, suggesting it may play a role in malignant transformation. [provided by RefSeq, Jul 2008]
Human IMPDH2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC124949 | View Product |
| AAV Vector & Virus | Long-term expression | VC124949 | View Product |
| Adenovirus | Transient expression | A124949 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG124949 | View Product |
| Gene knockout (non-viral) | PG124949 | View Product | |
| Gene knockout (AAV) | VG124949 | View Product | |
| CRISPR Activation | Gene activation | LA124949 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS124949 | View Product |
| Gene knockdown (AAV) | VS124949 | View Product | |
| ORF Vector | Template DNA | PC124949 | View Product |
Mouse Impdh2 Gene Overview
| Gene Name | inosine monophosphate dehydrogenase 2 |
|---|---|
| Gene Symbol | Impdh2 |
| Synonyms | IMPD,IMPD 2,IMPDH-II |
| NCBI ID | 23918 |
| Ensembl ID | ENSMUSG00000062867 |
| Uniprot ID | P24547 |
| Gene Type | Protein coding |
Gene Summary
Enables IMP dehydrogenase activity. Involved in 'de novo' XMP biosynthetic process and GMP biosynthetic process. Acts upstream of or within cellular response to interleukin-4; lymphocyte proliferation; and purine nucleotide biosynthetic process. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in several structures, including alimentary system; brain; heart; respiratory system; and sensory organ. Orthologous to human IMPDH2 (inosine monophosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Impdh2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC424949 | View Product |
| AAV Vector & Virus | Long-term expression | VC424949 | View Product |
| Adenovirus | Transient expression | A424949 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG424949 | View Product |
| Gene knockout (non-viral) | PG424949 | View Product | |
| Gene knockout (AAV) | VG424949 | View Product | |
| CRISPR Activation | Gene activation | LA424949 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS424949 | View Product |
| Gene knockdown (AAV) | VS424949 | View Product | |
| ORF Vector | Template DNA | PC424949 | View Product |
Rat Impdh2 Gene Overview
| Gene Name | inosine monophosphate dehydrogenase 2 |
|---|---|
| Gene Symbol | Impdh2 |
| Synonyms | IMPD 2,IMPDH 2 |
| NCBI ID | 301005 |
| Ensembl ID | ENSRNOG00000031965 |
| Uniprot ID | E9PU28 |
| Gene Type | Protein coding |
Gene Summary
Enables IMP dehydrogenase activity and identical protein binding activity. Involved in retina development in camera-type eye. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Orthologous to human IMPDH2 (inosine monophosphate dehydrogenase 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Impdh2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC624949 | View Product |
| AAV Vector & Virus | Long-term expression | VC624949 | View Product |
| Adenovirus | Transient expression | A624949 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG624949 | View Product |
| Gene knockout (non-viral) | PG624949 | View Product | |
| Gene knockout (AAV) | VG624949 | View Product | |
| CRISPR Activation | Gene activation | LA624949 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS624949 | View Product |
| Gene knockdown (AAV) | VS624949 | View Product | |
| ORF Vector | Template DNA | PC624949 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |