INSR Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use INSR-specific vectors and viral particles designed for reliable INSR overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including INSR CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human INSR Gene Overview
| Gene Name | insulin receptor |
|---|---|
| Gene Symbol | INSR |
| Synonyms | HHF5,CD220 |
| NCBI ID | 3643 |
| Ensembl ID | ENSG00000171105 |
| Uniprot ID | P06213 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Human INSR Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC125002 | View Product |
| Adenovirus | Transient expression | A125002 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG125002 | View Product |
| Gene knockout (non-viral) | PG125002 | View Product | |
| Gene knockout (AAV) | VG125002 | View Product | |
| CRISPR Activation | Gene activation | LA125002 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS125002 | View Product |
| Gene knockdown (AAV) | VS125002 | View Product | |
| ORF Vector | Template DNA | PC125002 | View Product |
Mouse Insr Gene Overview
| Gene Name | insulin receptor |
|---|---|
| Gene Symbol | Insr |
| Synonyms | IR,IR-A,IR-B,CD220,4932439J01Rik,D630014A15Rik |
| NCBI ID | 16337 |
| Ensembl ID | ENSMUSG00000005534 |
| Uniprot ID | P15208 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the receptor tyrosine kinase family of transmembrane signaling proteins that play important roles in cell differentiation, growth and metabolism. The encoded preproprotein undergoes proteolytic processing to generate alpha and beta chains that form a disulfide-linked heterodimer which, in turn homodimerizes to form a mature, functional receptor. Mice lacking the encoded protein develop severe hyperglycemia and hyperketonemia, and die within a couple of days after birth as a result of diabetic ketoacidosis. [provided by RefSeq, Aug 2016]
Mouse Insr Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC425002 | View Product |
| Adenovirus | Transient expression | A425002 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG425002 | View Product |
| Gene knockout (non-viral) | PG425002 | View Product | |
| Gene knockout (AAV) | VG425002 | View Product | |
| CRISPR Activation | Gene activation | LA425002 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS425002 | View Product |
| Gene knockdown (AAV) | VS425002 | View Product | |
| ORF Vector | Template DNA | PC425002 | View Product |
Rat Insr Gene Overview
| Gene Name | insulin receptor |
|---|---|
| Gene Symbol | Insr |
| Synonyms | |
| NCBI ID | 24954 |
| Ensembl ID | ENSRNOG00000029986 |
| Uniprot ID | P15127 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including enzyme binding activity; insulin binding activity; and insulin receptor activity. Involved in several processes, including neuron projection organization; protein phosphorylation; and regulation of primary metabolic process. Located in several cellular components, including dendrite membrane; external side of plasma membrane; and neuronal cell body membrane. Used to study chronic kidney disease; diabetic neuropathy; liver disease (multiple); and type 2 diabetes mellitus. Biomarker of several diseases, including Alzheimer's disease; diabetes mellitus (multiple); hepatic encephalopathy; liver disease (multiple); and short bowel syndrome. Human ortholog(s) of this gene implicated in Donohue syndrome; glucose metabolism disease (multiple); and reproductive organ cancer (multiple). Orthologous to human INSR (insulin receptor). [provided by Alliance of Genome Resources, Jul 2025]
Rat Insr Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC625002 | View Product |
| Adenovirus | Transient expression | A625002 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG625002 | View Product |
| Gene knockout (non-viral) | PG625002 | View Product | |
| Gene knockout (AAV) | VG625002 | View Product | |
| CRISPR Activation | Gene activation | LA625002 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS625002 | View Product |
| Gene knockdown (AAV) | VS625002 | View Product | |
| ORF Vector | Template DNA | PC625002 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |