IREB2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use IREB2-specific vectors and viral particles designed for reliable IREB2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including IREB2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human IREB2 Gene Overview
| Gene Name | iron responsive element binding protein 2 |
|---|---|
| Gene Symbol | IREB2 |
| Synonyms | ACO3,IRP2,IRP2AD,NDCAMA,IRE-BP2,IRE-BP 2 |
| NCBI ID | 3658 |
| Ensembl ID | ENSG00000136381 |
| Uniprot ID | P48200 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is an RNA-binding protein that acts to regulate iron levels in the cells by regulating the translation and stability of mRNAs that affect iron homeostasis under conditions when iron is depleted. When iron levels are low, this protein binds to iron-responsive elements (IRES), stem-loop structures located either in the 5' or 3' UTRs. Binding to the 5' UTR represses translation, while binding to the 3' UTR inhibits mRNA degradation. When iron is found in the cell, this protein is degraded in a F-box and leucine rich repeat protein 5-dependent manner. Variants in this gene have been associated with lung cancer and chronic obstructive pulmonary disease (COPD). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
Human IREB2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC125076 | View Product |
| AAV Vector & Virus | Long-term expression | VC125076 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG125076 | View Product |
| Gene knockout (non-viral) | PG125076 | View Product | |
| Gene knockout (AAV) | VG125076 | View Product | |
| CRISPR Activation | Gene activation | LA125076 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS125076 | View Product |
| Gene knockdown (AAV) | VS125076 | View Product | |
| ORF Vector | Template DNA | PC125076 | View Product |
Mouse Ireb2 Gene Overview
| Gene Name | iron responsive element binding protein 2 |
|---|---|
| Gene Symbol | Ireb2 |
| Synonyms | Irp2,D9Ertd85e |
| NCBI ID | 64602 |
| Ensembl ID | ENSMUSG00000032293 |
| Uniprot ID | Q811J3 |
| Gene Type | Protein coding |
Gene Summary
Enables iron-responsive element binding activity. Involved in osteoclast differentiation. Acts upstream of or within several processes, including erythrocyte homeostasis; multicellular organismal-level iron ion homeostasis; and protoporphyrinogen IX biosynthetic process. Located in cytosol. Is expressed in several structures, including genitourinary system; hemolymphoid system gland; liver; nervous system; and yolk sac. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Ireb2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC425076 | View Product |
| AAV Vector & Virus | Long-term expression | VC425076 | View Product |
| Adenovirus | Transient expression | A425076 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG425076 | View Product |
| Gene knockout (non-viral) | PG425076 | View Product | |
| Gene knockout (AAV) | VG425076 | View Product | |
| CRISPR Activation | Gene activation | LA425076 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS425076 | View Product |
| Gene knockdown (AAV) | VS425076 | View Product | |
| ORF Vector | Template DNA | PC425076 | View Product |
Rat Ireb2 Gene Overview
| Gene Name | iron responsive element binding protein 2 |
|---|---|
| Gene Symbol | Ireb2 |
| Synonyms | Irp2 |
| NCBI ID | 64831 |
| Ensembl ID | ENSRNOG00000013271 |
| Uniprot ID | Q62751 |
| Gene Type | Protein coding |
Gene Summary
Enables 4 iron, 4 sulfur cluster binding activity; iron-responsive element binding activity; and regulatory region RNA binding activity. Involved in several processes, including cellular response to epidermal growth factor stimulus; cellular response to iron(III) ion; and response to hypoxia. Located in axon and neuronal cell body. Used to study anemia. Biomarker of anemia; hyperinsulinism; and iron deficiency anemia. Human ortholog(s) of this gene implicated in Alzheimer's disease. Orthologous to human IREB2 (iron responsive element binding protein 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Ireb2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC625076 | View Product |
| AAV Vector & Virus | Long-term expression | VC625076 | View Product |
| Adenovirus | Transient expression | A625076 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG625076 | View Product |
| Gene knockout (non-viral) | PG625076 | View Product | |
| Gene knockout (AAV) | VG625076 | View Product | |
| CRISPR Activation | Gene activation | LA625076 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS625076 | View Product |
| Gene knockdown (AAV) | VS625076 | View Product | |
| ORF Vector | Template DNA | PC625076 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |