IRF1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use IRF1-specific vectors and viral particles designed for reliable IRF1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including IRF1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human IRF1 Gene Overview
| Gene Name | interferon regulatory factor 1 |
|---|---|
| Gene Symbol | IRF1 |
| Synonyms | MAR,IRF-1,IMD117 |
| NCBI ID | 3659 |
| Ensembl ID | ENSG00000125347 |
| Uniprot ID | P10914 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017]
Human IRF1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC125077 | View Product |
| AAV Vector & Virus | Long-term expression | VC125077 | View Product |
| Adenovirus | Transient expression | A125077 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG125077 | View Product |
| Gene knockout (non-viral) | PG125077 | View Product | |
| Gene knockout (AAV) | VG125077 | View Product | |
| CRISPR Activation | Gene activation | LA125077 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS125077 | View Product |
| Gene knockdown (AAV) | VS125077 | View Product | |
| ORF Vector | Template DNA | PC125077 | View Product |
Mouse Irf1 Gene Overview
| Gene Name | interferon regulatory factor 1 |
|---|---|
| Gene Symbol | Irf1 |
| Synonyms | Irf-1 |
| NCBI ID | 16362 |
| Ensembl ID | ENSMUSG00000018899 |
| Uniprot ID | P15314 |
| Gene Type | Protein coding |
Gene Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in several processes, including defense response to other organism; regulation of T cell activation; and regulation of gene expression. Acts upstream of or within CD8-positive, alpha-beta T cell differentiation; positive regulation of interleukin-12 production; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including bone marrow; early conceptus; eye; genitourinary system; and gut. Human ortholog(s) of this gene implicated in asthma; immunodeficiency 117; lung cancer (multiple); smallpox; and stomach cancer (multiple). Orthologous to human IRF1 (interferon regulatory factor 1). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Irf1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC425077 | View Product |
| Stable overexpression | LC525077 | View Product | |
| AAV Vector & Virus | Long-term expression | VC425077 | View Product |
| Long-term expression | VC525077 | View Product | |
| Adenovirus | Transient expression | A425077 | View Product |
| Transient expression | A525077 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG425077 | View Product |
| Gene knockout (non-viral) | PG425077 | View Product | |
| Gene knockout (AAV) | VG425077 | View Product | |
| CRISPR Activation | Gene activation | LA425077 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS425077 | View Product |
| Gene knockdown (AAV) | VS425077 | View Product | |
| ORF Vector | Template DNA | PC425077 | View Product |
| Template DNA | PC525077 | View Product |
Rat Irf1 Gene Overview
| Gene Name | interferon regulatory factor 1 |
|---|---|
| Gene Symbol | Irf1 |
| Synonyms | |
| NCBI ID | 24508 |
| Ensembl ID | ENSRNOG00000008144 |
| Uniprot ID | P23570 |
| Gene Type | Protein coding |
Gene Summary
Enables sequence-specific DNA binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to exogenous dsRNA; and regulation of primary metabolic process. Predicted to be located in chromatin and cytoplasm. Predicted to be active in nucleus. Used to study endometrial adenocarcinoma. Biomarker of allergic conjunctivitis; lung disease; respiratory syncytial virus infectious disease; and ureteral obstruction. Human ortholog(s) of this gene implicated in asthma; immunodeficiency 117; lung cancer (multiple); smallpox; and stomach cancer (multiple). Orthologous to human IRF1 (interferon regulatory factor 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Irf1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC625077 | View Product |
| AAV Vector & Virus | Long-term expression | VC625077 | View Product |
| Adenovirus | Transient expression | A625077 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG625077 | View Product |
| Gene knockout (non-viral) | PG625077 | View Product | |
| Gene knockout (AAV) | VG625077 | View Product | |
| CRISPR Activation | Gene activation | LA625077 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS625077 | View Product |
| Gene knockdown (AAV) | VS625077 | View Product | |
| ORF Vector | Template DNA | PC625077 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |