IRF3 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use IRF3-specific vectors and viral particles designed for reliable IRF3 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including IRF3 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human IRF3 Gene Overview
| Gene Name | interferon regulatory factor 3 |
|---|---|
| Gene Symbol | IRF3 |
| Synonyms | IIAE7 |
| NCBI ID | 3661 |
| Ensembl ID | ENSG00000126456 |
| Uniprot ID | Q14653 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the interferon regulatory transcription factor (IRF) family. The encoded protein is found in an inactive cytoplasmic form that upon serine/threonine phosphorylation forms a complex with CREBBP. This complex translocates to the nucleus and activates the transcription of interferons alpha and beta, as well as other interferon-induced genes. The protein plays an important role in the innate immune response against DNA and RNA viruses. Mutations in this gene are associated with Encephalopathy, acute, infection-induced, herpes-specific, 7. [provided by RefSeq, Sep 2020]
Human IRF3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC125082 | View Product |
| AAV Vector & Virus | Long-term expression | VC125082 | View Product |
| Adenovirus | Transient expression | A125082 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG125082 | View Product |
| Gene knockout (non-viral) | PG125082 | View Product | |
| Gene knockout (AAV) | VG125082 | View Product | |
| CRISPR Activation | Gene activation | LA125082 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS125082 | View Product |
| Gene knockdown (AAV) | VS125082 | View Product | |
| ORF Vector | Template DNA | PC125082 | View Product |
Mouse Irf3 Gene Overview
| Gene Name | interferon regulatory factor 3 |
|---|---|
| Gene Symbol | Irf3 |
| Synonyms | IRF-3,C920001K05Rik |
| NCBI ID | 54131 |
| Ensembl ID | ENSMUSG00000003184 |
| Uniprot ID | P70671 |
| Gene Type | Protein coding |
Gene Summary
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; identical protein binding activity; and promoter-specific chromatin binding activity. Involved in positive regulation of macromolecule biosynthetic process; response to virus; and type I interferon-mediated signaling pathway. Acts upstream of or within several processes, including lipopolysaccharide-mediated signaling pathway; regulation of defense response; and response to exogenous dsRNA. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; eye; and genitourinary system. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human IRF3 (interferon regulatory factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Irf3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC425082 | View Product |
| AAV Vector & Virus | Long-term expression | VC425082 | View Product |
| Adenovirus | Transient expression | A425082 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG425082 | View Product |
| Gene knockout (non-viral) | PG425082 | View Product | |
| Gene knockout (AAV) | VG425082 | View Product | |
| CRISPR Activation | Gene activation | LA425082 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS425082 | View Product |
| Gene knockdown (AAV) | VS425082 | View Product | |
| ORF Vector | Template DNA | PC425082 | View Product |
Rat Irf3 Gene Overview
| Gene Name | interferon regulatory factor 3 |
|---|---|
| Gene Symbol | Irf3 |
| Synonyms | |
| NCBI ID | 292892 |
| Ensembl ID | ENSRNOG00000043388 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; promoter-specific chromatin binding activity; and protein homodimerization activity. Involved in cellular response to exogenous dsRNA; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of cytokine production. Predicted to be located in cytosol and mitochondrion. Predicted to be active in chromatin; cytoplasm; and nucleus. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human IRF3 (interferon regulatory factor 3). [provided by Alliance of Genome Resources, Jul 2025]
Rat Irf3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC625082 | View Product |
| AAV Vector & Virus | Long-term expression | VC625082 | View Product |
| Adenovirus | Transient expression | A625082 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG625082 | View Product |
| Gene knockout (non-viral) | PG625082 | View Product | |
| Gene knockout (AAV) | VG625082 | View Product | |
| CRISPR Activation | Gene activation | LA625082 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS625082 | View Product |
| Gene knockdown (AAV) | VS625082 | View Product | |
| ORF Vector | Template DNA | PC625082 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |