IRF4 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use IRF4-specific vectors and viral particles designed for reliable IRF4 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including IRF4 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human IRF4 Gene Overview
| Gene Name | interferon regulatory factor 4 |
|---|---|
| Gene Symbol | IRF4 |
| Synonyms | MUM1,LSIRF,SHEP8,IMD131,NF-EM5 |
| NCBI ID | 3662 |
| Ensembl ID | ENSG00000137265 |
| Uniprot ID | Q15306 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene belongs to the IRF (interferon regulatory factor) family of transcription factors, characterized by an unique tryptophan pentad repeat DNA-binding domain. The IRFs are important in the regulation of interferons in response to infection by virus, and in the regulation of interferon-inducible genes. This family member is lymphocyte specific and negatively regulates Toll-like-receptor (TLR) signaling that is central to the activation of innate and adaptive immune systems. A chromosomal translocation involving this gene and the IgH locus, t(6;14)(p25;q32), may be a cause of multiple myeloma. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2010]
Human IRF4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC125083 | View Product |
| AAV Vector & Virus | Long-term expression | VC125083 | View Product |
| Adenovirus | Transient expression | A125083 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG125083 | View Product |
| Gene knockout (non-viral) | PG125083 | View Product | |
| Gene knockout (AAV) | VG125083 | View Product | |
| CRISPR Activation | Gene activation | LA125083 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS125083 | View Product |
| Gene knockdown (AAV) | VS125083 | View Product | |
| ORF Vector | Template DNA | PC125083 | View Product |
Mouse Irf4 Gene Overview
| Gene Name | interferon regulatory factor 4 |
|---|---|
| Gene Symbol | Irf4 |
| Synonyms | Spip,IRF-4,LSIRF,NF-EM5 |
| NCBI ID | 16364 |
| Ensembl ID | ENSMUSG00000021356 |
| Uniprot ID | Q64287 |
| Gene Type | Protein coding |
Gene Summary
Enables DNA-binding transcription factor activity; cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator activity. Involved in defense response to protozoan; mononuclear cell differentiation; and positive regulation of metabolic process. Acts upstream of or within chromatin remodeling; negative regulation of toll-like receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Part of nucleosome. Is expressed in several structures, including eye; hemolymphoid system; liver; mandible; and testis. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and pigmentation disease. Orthologous to human IRF4 (interferon regulatory factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Irf4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC425083 | View Product |
| AAV Vector & Virus | Long-term expression | VC425083 | View Product |
| Adenovirus | Transient expression | A425083 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG425083 | View Product |
| Gene knockout (non-viral) | PG425083 | View Product | |
| Gene knockout (AAV) | VG425083 | View Product | |
| CRISPR Activation | Gene activation | LA425083 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS425083 | View Product |
| Gene knockdown (AAV) | VS425083 | View Product | |
| ORF Vector | Template DNA | PC425083 | View Product |
Rat Irf4 Gene Overview
| Gene Name | interferon regulatory factor 4 |
|---|---|
| Gene Symbol | Irf4 |
| Synonyms | |
| NCBI ID | 291100 |
| Ensembl ID | ENSRNOG00000061070 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and transcription coactivator activity. Predicted to be involved in several processes, including T-helper 17 cell lineage commitment; defense response to protozoan; and positive regulation of macromolecule biosynthetic process. Predicted to act upstream of or within several processes, including myeloid dendritic cell differentiation; negative regulation of toll-like receptor signaling pathway; and positive regulation of transcription by RNA polymerase II. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of nucleosome. Predicted to be active in nucleus. Biomarker of middle cerebral artery infarction. Human ortholog(s) of this gene implicated in hematologic cancer (multiple) and pigmentation disease. Orthologous to human IRF4 (interferon regulatory factor 4). [provided by Alliance of Genome Resources, Jul 2025]
Rat Irf4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC625083 | View Product |
| AAV Vector & Virus | Long-term expression | VC625083 | View Product |
| Adenovirus | Transient expression | A625083 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG625083 | View Product |
| Gene knockout (non-viral) | PG625083 | View Product | |
| Gene knockout (AAV) | VG625083 | View Product | |
| CRISPR Activation | Gene activation | LA625083 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS625083 | View Product |
| Gene knockdown (AAV) | VS625083 | View Product | |
| ORF Vector | Template DNA | PC625083 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |