IRF8 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use IRF8-specific vectors and viral particles designed for reliable IRF8 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including IRF8 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human IRF8 Gene Overview
| Gene Name | interferon regulatory factor 8 |
|---|---|
| Gene Symbol | IRF8 |
| Synonyms | ICSBP,IRF-8,ICSBP1,IMD32A,IMD32B,H-ICSBP |
| NCBI ID | 3394 |
| Ensembl ID | ENSG00000140968 |
| Uniprot ID | Q02556 |
| Gene Type | Protein coding |
Gene Summary
Interferon consensus sequence-binding protein (ICSBP) is a transcription factor of the interferon (IFN) regulatory factor (IRF) family. Proteins of this family are composed of a conserved DNA-binding domain in the N-terminal region and a divergent C-terminal region that serves as the regulatory domain. The IRF family proteins bind to the IFN-stimulated response element (ISRE) and regulate expression of genes stimulated by type I IFNs, namely IFN-alpha and IFN-beta. IRF family proteins also control expression of IFN-alpha and IFN-beta-regulated genes that are induced by viral infection. [provided by RefSeq, Jul 2008]
Human IRF8 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC125088 | View Product |
| AAV Vector & Virus | Long-term expression | VC125088 | View Product |
| Adenovirus | Transient expression | A125088 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG125088 | View Product |
| Gene knockout (non-viral) | PG125088 | View Product | |
| Gene knockout (AAV) | VG125088 | View Product | |
| CRISPR Activation | Gene activation | LA125088 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS125088 | View Product |
| Gene knockdown (AAV) | VS125088 | View Product | |
| ORF Vector | Template DNA | PC125088 | View Product |
Mouse Irf8 Gene Overview
| Gene Name | interferon regulatory factor 8 |
|---|---|
| Gene Symbol | Irf8 |
| Synonyms | Myls,ICSBP,IRF-8,Icsbp1 |
| NCBI ID | 15900 |
| Ensembl ID | ENSMUSG00000041515 |
| Uniprot ID | P23611 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a transcription factor that belongs to the interferon regulatory factor family. Proteins belonging to this family have a DNA binding domain at the amino terminus that contains five well-conserved tryptophan-rich repeats. This domain recognizes DNA sequences similar to the interferon-stimulated response element. The protein encoded by this gene promotes or suppresses lineage-specific genes to regulate the differentation of lymphoid and myeloid lineage cells. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]
Mouse Irf8 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC425088 | View Product |
| AAV Vector & Virus | Long-term expression | VC425088 | View Product |
| Adenovirus | Transient expression | A425088 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG425088 | View Product |
| Gene knockout (non-viral) | PG425088 | View Product | |
| Gene knockout (AAV) | VG425088 | View Product | |
| CRISPR Activation | Gene activation | LA425088 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS425088 | View Product |
| Gene knockdown (AAV) | VS425088 | View Product | |
| ORF Vector | Template DNA | PC425088 | View Product |
Rat Irf8 Gene Overview
| Gene Name | interferon regulatory factor 8 |
|---|---|
| Gene Symbol | Irf8 |
| Synonyms | ICSBP,Icsbp1 |
| NCBI ID | 292060 |
| Ensembl ID | ENSRNOG00000017869 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in cellular response to type II interferon and positive regulation of apoptotic process. Predicted to be located in cytoplasm and nucleoplasm. Human ortholog(s) of this gene implicated in Behcet's disease; immunodeficiency 32A; immunodeficiency 32B; multiple myeloma; and systemic lupus erythematosus. Orthologous to human IRF8 (interferon regulatory factor 8). [provided by Alliance of Genome Resources, Apr 2025]
Rat Irf8 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC625088 | View Product |
| AAV Vector & Virus | Long-term expression | VC625088 | View Product |
| Adenovirus | Transient expression | A625088 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG625088 | View Product |
| Gene knockout (non-viral) | PG625088 | View Product | |
| Gene knockout (AAV) | VG625088 | View Product | |
| CRISPR Activation | Gene activation | LA625088 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS625088 | View Product |
| Gene knockdown (AAV) | VS625088 | View Product | |
| ORF Vector | Template DNA | PC625088 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |