ISG15 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use ISG15-specific vectors and viral particles designed for reliable ISG15 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including ISG15 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human ISG15 Gene Overview
| Gene Name | ISG15 ubiquitin like modifier |
|---|---|
| Gene Symbol | ISG15 |
| Synonyms | G1P2,IP17,UCRP,IFI15,IMD38,hUCRP |
| NCBI ID | 9636 |
| Ensembl ID | ENSG00000187608 |
| Uniprot ID | P05161 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]
Human ISG15 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC125121 | View Product |
| AAV Vector & Virus | Long-term expression | VC125121 | View Product |
| Adenovirus | Transient expression | A125121 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG125121 | View Product |
| Gene knockout (non-viral) | PG125121 | View Product | |
| Gene knockout (AAV) | VG125121 | View Product | |
| CRISPR Activation | Gene activation | LA125121 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS125121 | View Product |
| Gene knockdown (AAV) | VS125121 | View Product | |
| ORF Vector | Template DNA | PC125121 | View Product |
Mouse Isg15 Gene Overview
| Gene Name | ISG15 ubiquitin-like modifier |
|---|---|
| Gene Symbol | Isg15 |
| Synonyms | G1p2,IP17,Irfp,UCRP,IGI15 |
| NCBI ID | 100038882 |
| Ensembl ID | ENSMUSG00000035692 |
| Uniprot ID | Q64339 |
| Gene Type | Protein coding |
Gene Summary
Enables protein tag activity. Involved in several processes, including ISG15-protein conjugation; defense response to other organism; and positive regulation of erythrocyte differentiation. Acts upstream of or within modification-dependent protein catabolic process and response to bacterium. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and nucleus. Is expressed in brain; decidua; embryo; labyrinthine zone; and mesometrium. Human ortholog(s) of this gene implicated in immunodeficiency 38. Orthologous to human ISG15 (ISG15 ubiquitin like modifier). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Isg15 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC425121 | View Product |
| AAV Vector & Virus | Long-term expression | VC425121 | View Product |
| Adenovirus | Transient expression | A425121 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG425121 | View Product |
| Gene knockout (non-viral) | PG425121 | View Product | |
| Gene knockout (AAV) | VG425121 | View Product | |
| CRISPR Activation | Gene activation | LA425121 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS425121 | View Product |
| Gene knockdown (AAV) | VS425121 | View Product | |
| ORF Vector | Template DNA | PC425121 | View Product |
Rat Isg15 Gene Overview
| Gene Name | ISG15 ubiquitin-like modifier |
|---|---|
| Gene Symbol | Isg15 |
| Synonyms | G1p2 |
| NCBI ID | 298693 |
| Ensembl ID | ENSRNOG00000069527 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable integrin binding activity; protein tag activity; and ubiquitin protein ligase binding activity. Predicted to be involved in several processes, including ISG15-protein conjugation; defense response to other organism; and positive regulation of cytokine production. Predicted to act upstream of or within response to bacterium. Predicted to be located in extracellular region. Predicted to be active in cytoplasm and nucleus. Human ortholog(s) of this gene implicated in immunodeficiency 38. Orthologous to human ISG15 (ISG15 ubiquitin like modifier). [provided by Alliance of Genome Resources, Apr 2025]
Rat Isg15 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC625121 | View Product |
| AAV Vector & Virus | Long-term expression | VC625121 | View Product |
| Adenovirus | Transient expression | A625121 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG625121 | View Product |
| Gene knockout (non-viral) | PG625121 | View Product | |
| Gene knockout (AAV) | VG625121 | View Product | |
| CRISPR Activation | Gene activation | LA625121 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS625121 | View Product |
| Gene knockdown (AAV) | VS625121 | View Product | |
| ORF Vector | Template DNA | PC625121 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |