JAK2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use JAK2-specific vectors and viral particles designed for reliable JAK2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including JAK2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human JAK2 Gene Overview
| Gene Name | Janus kinase 2 |
|---|---|
| Gene Symbol | JAK2 |
| Synonyms | JTK10 |
| NCBI ID | 3717 |
| Ensembl ID | ENSG00000096968 |
| Uniprot ID | O60674 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a non-receptor tyrosine kinase that plays a central role in cytokine and growth factor signalling. The primary isoform of this protein has an N-terminal FERM domain that is required for erythropoietin receptor association, an SH2 domain that binds STAT transcription factors, a pseudokinase domain and a C-terminal tyrosine kinase domain. Cytokine binding induces autophosphorylation and activation of this kinase. This kinase then recruits and phosphorylates signal transducer and activator of transcription (STAT) proteins. Growth factors like TGF-beta 1 also induce phosphorylation and activation of this kinase and translocation of downstream STAT proteins to the nucleus where they influence gene transcription. Mutations in this gene are associated with numerous inflammatory diseases and malignancies. This gene is a downstream target of the pleiotropic cytokine IL6 that is produced by B cells, T cells, dendritic cells and macrophages to produce an immune response or inflammation. Disregulation of the IL6/JAK2/STAT3 signalling pathways produces increased cellular proliferation and myeloproliferative neoplasms of hematopoietic stem cells. A nonsynonymous mutation in the pseudokinase domain of this gene disrupts the domains inhibitory effect and results in constitutive tyrosine phosphorylation activity and hypersensitivity to cytokine signalling. This gene and the IL6/JAK2/STAT3 signalling pathway is a therapeutic target for the treatment of excessive inflammatory responses to viral infections. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2020]
Human JAK2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC125227 | View Product |
| AAV Vector & Virus | Long-term expression | VC125227 | View Product |
| Adenovirus | Transient expression | A125227 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG125227 | View Product |
| Gene knockout (non-viral) | PG125227 | View Product | |
| Gene knockout (AAV) | VG125227 | View Product | |
| CRISPR Activation | Gene activation | LA125227 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS125227 | View Product |
| Gene knockdown (AAV) | VS125227 | View Product | |
| ORF Vector | Template DNA | PC125227 | View Product |
Mouse Jak2 Gene Overview
| Gene Name | Janus kinase 2 |
|---|---|
| Gene Symbol | Jak2 |
| Synonyms | Fd17 |
| NCBI ID | 16452 |
| Ensembl ID | ENSMUSG00000024789 |
| Uniprot ID | Q62120 |
| Gene Type | Protein coding |
Gene Summary
Enables interleukin-12 receptor binding activity; non-membrane spanning protein tyrosine kinase activity; and signaling receptor activator activity. Involved in several processes, including cell surface receptor signaling pathway; hemopoiesis; and positive regulation of metabolic process. Acts upstream of or within several processes, including cell surface receptor signaling pathway; cellular response to dexamethasone stimulus; and regulation of apoptotic process. Located in caveola and nucleus. Is active in cytosol. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; liver and biliary system; and musculoskeletal system. Used to study essential thrombocythemia; myelofibrosis; myeloproliferative neoplasm; and polycythemia vera. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Jak2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC425227 | View Product |
| Stable overexpression | LC525227 | View Product | |
| Adenovirus | Transient expression | A425227 | View Product |
| Transient expression | A525227 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG425227 | View Product |
| Gene knockout (non-viral) | PG425227 | View Product | |
| Gene knockout (AAV) | VG425227 | View Product | |
| CRISPR Activation | Gene activation | LA425227 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS425227 | View Product |
| Gene knockdown (AAV) | VS425227 | View Product | |
| ORF Vector | Template DNA | PC425227 | View Product |
| Template DNA | PC525227 | View Product |
Rat Jak2 Gene Overview
| Gene Name | Janus kinase 2 |
|---|---|
| Gene Symbol | Jak2 |
| Synonyms | |
| NCBI ID | 24514 |
| Ensembl ID | ENSRNOG00000059968 |
| Uniprot ID | Q62689 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including insulin receptor substrate binding activity; phosphatidylinositol 3-kinase binding activity; and signaling receptor binding activity. Involved in several processes, including cell surface receptor signaling pathway; regulation of apoptotic process; and regulation of biosynthetic process. Located in euchromatin. Is active in glutamatergic synapse and postsynapse. Used to study several diseases, including hyperuricemia; liver disease (multiple); retinal detachment; thrombocytosis; and transient cerebral ischemia. Biomarker of atherosclerosis; gastrointestinal system cancer (multiple); heart disease; liver cirrhosis; and obesity. Human ortholog(s) of this gene implicated in several diseases, including gastrointestinal system cancer (multiple); hematologic cancer (multiple); hepatic vascular disease (multiple); inflammatory bowel disease (multiple); and lung non-small cell carcinoma (multiple). Orthologous to human JAK2 (Janus kinase 2). [provided by Alliance of Genome Resources, Apr 2025]
Rat Jak2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC625227 | View Product |
| Adenovirus | Transient expression | A625227 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG625227 | View Product |
| Gene knockout (non-viral) | PG625227 | View Product | |
| Gene knockout (AAV) | VG625227 | View Product | |
| CRISPR Activation | Gene activation | LA625227 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS625227 | View Product |
| Gene knockdown (AAV) | VS625227 | View Product | |
| ORF Vector | Template DNA | PC625227 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |