KRAS Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use KRAS-specific vectors and viral particles designed for reliable KRAS overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including KRAS CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human KRAS Gene Overview
| Gene Name | KRAS proto-oncogene, GTPase |
|---|---|
| Gene Symbol | KRAS |
| Synonyms | NS,NS3,OES,CFC2,RALD,K-Ras,KRAS1,KRAS2,RALD2,RASK2,KI-RAS,C-K-RAS,K-RAS2A,K-RAS2B,K-RAS4A,K-RAS4B,K-Ras 2,'C-K-RAS,c-Ki-ras,c-Ki-ras2 |
| NCBI ID | 3845 |
| Ensembl ID | ENSG00000133703 |
| Uniprot ID | P01116 |
| Gene Type | Protein coding |
Gene Summary
This gene, a Kirsten ras oncogene homolog from the mammalian ras gene family, encodes a protein that is a member of the small GTPase superfamily. A single amino acid substitution is responsible for an activating mutation. The transforming protein that results is implicated in various malignancies, including lung adenocarcinoma, mucinous adenoma, ductal carcinoma of the pancreas and colorectal carcinoma. Alternative splicing leads to variants encoding two isoforms that differ in the C-terminal region. [provided by RefSeq, Jul 2008]
Human KRAS Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC120337 | View Product |
| AAV Vector & Virus | Long-term expression | VC120337 | View Product |
| Adenovirus | Transient expression | A120337 | View Product |
| Transient expression | A225910 | View Product | |
| ORF Vector | Template DNA | PC120337 | View Product |
| Template DNA | PC225910 | View Product |
Mouse Kras Gene Overview
| Gene Name | Kras proto-oncogene, GTPase |
|---|---|
| Gene Symbol | Kras |
| Synonyms | ras,p21B,K-Ras,K-ras,Kras2,Ki-ras,Kras-2,K-Ras 2,c-K-ras,c-Ki-ras |
| NCBI ID | 16653 |
| Ensembl ID | ENSMUSG00000030265 |
| Uniprot ID | P32883 |
| Gene Type | Protein coding |
Gene Summary
Enables GTPase activity and protein-membrane adaptor activity. Acts upstream of or within several processes, including Ras protein signal transduction; forebrain astrocyte development; and modulation of chemical synaptic transmission. Located in membrane. Is expressed in several structures, including alimentary system; brain; eye; genitourinary system; and limb. Used to study several diseases, including Noonan syndrome 3; arteriovenous malformations of the brain; gastrointestinal system cancer (multiple); pancreatic carcinoma (multiple); and reproductive organ cancer (multiple). Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Kras Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC425910 | View Product |
| AAV Vector & Virus | Long-term expression | VC425910 | View Product |
| Adenovirus | Transient expression | A425910 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG425910 | View Product |
| Gene knockout (non-viral) | PG425910 | View Product | |
| Gene knockout (AAV) | VG425910 | View Product | |
| CRISPR Activation | Gene activation | LA425910 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS425910 | View Product |
| Gene knockdown (AAV) | VS425910 | View Product | |
| ORF Vector | Template DNA | PC425910 | View Product |
Rat Kras Gene Overview
| Gene Name | KRAS proto-oncogene, GTPase |
|---|---|
| Gene Symbol | Kras |
| Synonyms | p21,K-ras,Kras2,c-Ki-ras |
| NCBI ID | 24525 |
| Ensembl ID | ENSRNOG00000081425 |
| Uniprot ID | P08644 |
| Gene Type | Protein coding |
Gene Summary
Enables GDP binding activity; GMP binding activity; and LRR domain binding activity. Involved in several processes, including cardiac muscle cell proliferation; positive regulation of NF-kappaB transcription factor activity; and response to corticosteroid. Predicted to be located in cytoplasm and cytoplasmic side of plasma membrane. Predicted to be active in plasma membrane. Used to study bronchiolo-alveolar adenocarcinoma; endometrial adenocarcinoma; hepatocellular adenoma; hepatocellular carcinoma; and renal fibrosis. Biomarker of muscular atrophy. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome (multiple); cardiofaciocutaneous syndrome (multiple); gastrointestinal system cancer (multiple); hematologic cancer (multiple); and lung cancer (multiple). Orthologous to human KRAS (KRAS proto-oncogene, GTPase). [provided by Alliance of Genome Resources, Jul 2025]
Rat Kras Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC625910 | View Product |
| AAV Vector & Virus | Long-term expression | VC625910 | View Product |
| Adenovirus | Transient expression | A625910 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG625910 | View Product |
| Gene knockout (non-viral) | PG625910 | View Product | |
| Gene knockout (AAV) | VG625910 | View Product | |
| CRISPR Activation | Gene activation | LA625910 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS625910 | View Product |
| Gene knockdown (AAV) | VS625910 | View Product | |
| ORF Vector | Template DNA | PC625910 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |