LAG3 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use LAG3-specific vectors and viral particles designed for reliable LAG3 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including LAG3 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human LAG3 Gene Overview
| Gene Name | lymphocyte activating 3 |
|---|---|
| Gene Symbol | LAG3 |
| Synonyms | CD223 |
| NCBI ID | 3902 |
| Ensembl ID | ENSG00000089692 |
| Uniprot ID | P18627 |
| Gene Type | Protein coding |
Gene Summary
Lymphocyte-activation protein 3 belongs to Ig superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene contains 8 exons. The sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship of LAG3 to CD4. [provided by RefSeq, Jul 2008]
Human LAG3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC126264 | View Product |
| AAV Vector & Virus | Long-term expression | VC126264 | View Product |
| Adenovirus | Transient expression | A126264 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG126264 | View Product |
| Gene knockout (non-viral) | PG126264 | View Product | |
| Gene knockout (AAV) | VG126264 | View Product | |
| CRISPR Activation | Gene activation | LA126264 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS126264 | View Product |
| Gene knockdown (AAV) | VS126264 | View Product | |
| ORF Vector | Template DNA | PC126264 | View Product |
Mouse Lag3 Gene Overview
| Gene Name | lymphocyte-activation gene 3 |
|---|---|
| Gene Symbol | Lag3 |
| Synonyms | Ly66,CD223,LAG-3 |
| NCBI ID | 16768 |
| Ensembl ID | ENSMUSG00000030124 |
| Uniprot ID | Q61790 |
| Gene Type | Protein coding |
Gene Summary
Enables MHC class II protein binding activity and transmembrane signaling receptor activity. Involved in several processes, including cell surface receptor signaling pathway; negative regulation of regulatory T cell differentiation; and plasmacytoid dendritic cell activation. Acts upstream of or within negative regulation of interleukin-2 production and positive regulation of natural killer cell mediated cytotoxicity. Located in external side of plasma membrane and extracellular region. Orthologous to human LAG3 (lymphocyte activating 3). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Lag3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC426264 | View Product |
| AAV Vector & Virus | Long-term expression | VC426264 | View Product |
| Adenovirus | Transient expression | A426264 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG426264 | View Product |
| Gene knockout (non-viral) | PG426264 | View Product | |
| Gene knockout (AAV) | VG426264 | View Product | |
| CRISPR Activation | Gene activation | LA426264 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS426264 | View Product |
| Gene knockdown (AAV) | VS426264 | View Product | |
| ORF Vector | Template DNA | PC426264 | View Product |
Rat Lag3 Gene Overview
| Gene Name | lymphocyte activating 3 |
|---|---|
| Gene Symbol | Lag3 |
| Synonyms | CD223 |
| NCBI ID | 297596 |
| Ensembl ID | ENSRNOG00000021334 |
| Uniprot ID | Q5BK54 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable MHC class II protein binding activity and transmembrane signaling receptor activity. Predicted to be involved in several processes, including innate immune response; negative regulation of regulatory T cell differentiation; and plasmacytoid dendritic cell activation. Predicted to act upstream of or within negative regulation of T cell activation; negative regulation of interleukin-2 production; and positive regulation of natural killer cell mediated cytotoxicity. Predicted to be located in external side of plasma membrane and extracellular region. Predicted to be active in cell surface and plasma membrane. Orthologous to human LAG3 (lymphocyte activating 3). [provided by Alliance of Genome Resources, Jul 2025]
Rat Lag3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC626264 | View Product |
| AAV Vector & Virus | Long-term expression | VC626264 | View Product |
| Adenovirus | Transient expression | A626264 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG626264 | View Product |
| Gene knockout (non-viral) | PG626264 | View Product | |
| Gene knockout (AAV) | VG626264 | View Product | |
| CRISPR Activation | Gene activation | LA626264 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS626264 | View Product |
| Gene knockdown (AAV) | VS626264 | View Product | |
| ORF Vector | Template DNA | PC626264 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |