LATS1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use LATS1-specific vectors and viral particles designed for reliable LATS1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including LATS1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human LATS1 Gene Overview
| Gene Name | large tumor suppressor kinase 1 |
|---|---|
| Gene Symbol | LATS1 |
| Synonyms | wts,WARTS |
| NCBI ID | 9113 |
| Ensembl ID | ENSG00000131023 |
| Uniprot ID | O95835 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a putative serine/threonine kinase that localizes to the mitotic apparatus and complexes with cell cycle controller CDC2 kinase in early mitosis. The protein is phosphorylated in a cell-cycle dependent manner, with late prophase phosphorylation remaining through metaphase. The N-terminal region of the protein binds CDC2 to form a complex showing reduced H1 histone kinase activity, indicating a role as a negative regulator of CDC2/cyclin A. In addition, the C-terminal kinase domain binds to its own N-terminal region, suggesting potential negative regulation through interference with complex formation via intramolecular binding. Biochemical and genetic data suggest a role as a tumor suppressor. This is supported by studies in knockout mice showing development of soft-tissue sarcomas, ovarian stromal cell tumors and a high sensitivity to carcinogenic treatments. [provided by RefSeq, Apr 2017]
Human LATS1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Adenovirus | Transient expression | A226327 | View Product |
| ORF Vector | Template DNA | PC226327 | View Product |
Mouse Lats1 Gene Overview
| Gene Name | large tumor suppressor |
|---|---|
| Gene Symbol | Lats1 |
| Synonyms | |
| NCBI ID | 16798 |
| Ensembl ID | ENSMUSG00000040021 |
| Uniprot ID | Q8BYR2 |
| Gene Type | Protein coding |
Gene Summary
Enables protein serine/threonine kinase activity. Involved in hormone-mediated signaling pathway; negative regulation of protein localization to nucleus; and regulation of signal transduction. Acts upstream of or within several processes, including hippo signaling; inner cell mass cell differentiation; and keratinocyte differentiation. Predicted to be located in several cellular components, including centrosome; glutamatergic synapse; and midbody. Predicted to be active in cytoplasm and spindle pole. Is expressed in several structures, including central nervous system; early conceptus; lung; and otocyst. Orthologous to human LATS1 (large tumor suppressor kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Lats1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC426327 | View Product |
| Adenovirus | Transient expression | A426327 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG426327 | View Product |
| Gene knockout (non-viral) | PG426327 | View Product | |
| Gene knockout (AAV) | VG426327 | View Product | |
| CRISPR Activation | Gene activation | LA426327 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS426327 | View Product |
| Gene knockdown (AAV) | VS426327 | View Product | |
| ORF Vector | Template DNA | PC426327 | View Product |
Rat Lats1 Gene Overview
| Gene Name | large tumor suppressor kinase 1 |
|---|---|
| Gene Symbol | Lats1 |
| Synonyms | RGD1564085 |
| NCBI ID | 308265 |
| Ensembl ID | ENSRNOG00000014916 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including ATP binding activity; magnesium ion binding activity; and nuclear estrogen receptor binding activity. Involved in regulation of postsynaptic density assembly. Is active in glutamatergic synapse and postsynapse. Orthologous to human LATS1 (large tumor suppressor kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Lats1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |