LATS2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use LATS2-specific vectors and viral particles designed for reliable LATS2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including LATS2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human LATS2 Gene Overview
| Gene Name | large tumor suppressor kinase 2 |
|---|---|
| Gene Symbol | LATS2 |
| Synonyms | KPM |
| NCBI ID | 26524 |
| Ensembl ID | ENSG00000150457 |
| Uniprot ID | Q9NRM7 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
Human LATS2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| AAV Vector & Virus | Long-term expression | VC126328 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG126328 | View Product |
| Gene knockout (non-viral) | PG126328 | View Product | |
| Gene knockout (AAV) | VG126328 | View Product | |
| CRISPR Activation | Gene activation | LA126328 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS126328 | View Product |
| Gene knockdown (AAV) | VS126328 | View Product |
Mouse Lats2 Gene Overview
| Gene Name | large tumor suppressor 2 |
|---|---|
| Gene Symbol | Lats2 |
| Synonyms | 4932411G09Rik |
| NCBI ID | 50523 |
| Ensembl ID | ENSMUSG00000021959,ENSMUSG00000114942 |
| Uniprot ID | Q7TSJ6 |
| Gene Type | Protein coding |
Gene Summary
Enables protein serine/threonine kinase activity. Involved in G1/S transition of mitotic cell cycle; negative regulation of protein localization to nucleus; and regulation of signal transduction. Acts upstream of or within several processes, including hippo signaling; inner cell mass cell differentiation; and negative regulation of canonical Wnt signaling pathway. Located in spindle pole. Is expressed in several structures, including central nervous system; eye; genitourinary system; gut; and immune system. Orthologous to human LATS2 (large tumor suppressor kinase 2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Lats2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC426328 | View Product |
| Stable overexpression | LC526328 | View Product | |
| AAV Vector & Virus | Long-term expression | VC426328 | View Product |
| Long-term expression | VC526328 | View Product | |
| Adenovirus | Transient expression | A426328 | View Product |
| Transient expression | A526328 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG426328 | View Product |
| Gene knockout (non-viral) | PG426328 | View Product | |
| Gene knockout (AAV) | VG426328 | View Product | |
| CRISPR Activation | Gene activation | LA426328 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS426328 | View Product |
| Gene knockdown (AAV) | VS426328 | View Product | |
| ORF Vector | Template DNA | PC426328 | View Product |
| Template DNA | PC526328 | View Product |
Rat Lats2 Gene Overview
| Gene Name | large tumor suppressor kinase 2 |
|---|---|
| Gene Symbol | Lats2 |
| Synonyms | |
| NCBI ID | 305922 |
| Ensembl ID | ENSRNOG00000056343 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable ATP binding activity and protein serine/threonine kinase activity. Predicted to be involved in several processes, including G1/S transition of mitotic cell cycle; hippo signaling; and regulation of signal transduction. Predicted to act upstream of or within several processes, including inner cell mass cell differentiation; keratinocyte differentiation; and negative regulation of canonical Wnt signaling pathway. Predicted to be located in centriolar satellite and cytosol. Predicted to be active in cytoplasm; nucleus; and spindle pole. Orthologous to human LATS2 (large tumor suppressor kinase 2). [provided by Alliance of Genome Resources, Apr 2025]
Rat Lats2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC626328 | View Product |
| AAV Vector & Virus | Long-term expression | VC626328 | View Product |
| Adenovirus | Transient expression | A626328 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG626328 | View Product |
| Gene knockout (non-viral) | PG626328 | View Product | |
| Gene knockout (AAV) | VG626328 | View Product | |
| CRISPR Activation | Gene activation | LA626328 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS626328 | View Product |
| Gene knockdown (AAV) | VS626328 | View Product | |
| ORF Vector | Template DNA | PC626328 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |