LDLR Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use LDLR-specific vectors and viral particles designed for reliable LDLR overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including LDLR CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human LDLR Gene Overview
| Gene Name | low density lipoprotein receptor |
|---|---|
| Gene Symbol | LDLR |
| Synonyms | LDLCQ2 |
| NCBI ID | 3949 |
| Ensembl ID | ENSG00000130164 |
| Uniprot ID | P01130 |
| Gene Type | Protein coding |
Gene Summary
The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. The encoded protein is normally bound at the cell membrane, where it binds low density lipoprotein/cholesterol and is taken into the cell. Lysosomes release the cholesterol, which is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia. Alternate splicing results in multiple transcript variants.[provided by RefSeq, May 2022]
Human LDLR Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC126418 | View Product |
| AAV Vector & Virus | Long-term expression | VC126418 | View Product |
| Adenovirus | Transient expression | A126418 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG126418 | View Product |
| Gene knockout (non-viral) | PG126418 | View Product | |
| Gene knockout (AAV) | VG126418 | View Product | |
| CRISPR Activation | Gene activation | LA126418 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS126418 | View Product |
| Gene knockdown (AAV) | VS126418 | View Product | |
| ORF Vector | Template DNA | PC126418 | View Product |
Mouse Ldlr Gene Overview
| Gene Name | low density lipoprotein receptor |
|---|---|
| Gene Symbol | Ldlr |
| Synonyms | Hlb301 |
| NCBI ID | 16835 |
| Ensembl ID | ENSMUSG00000032193 |
| Uniprot ID | P35951 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including amyloid-beta binding activity; low-density lipoprotein particle binding activity; and low-density lipoprotein particle receptor activity. Involved in several processes, including endocytosis; regulation of inflammatory response; and regulation of primary metabolic process. Acts upstream of or within several processes, including cholesterol homeostasis; lipoprotein catabolic process; and low-density lipoprotein particle clearance. Located in several cellular components, including basolateral plasma membrane; endosome; and lysosome. Is expressed in several structures, including alimentary system; genitourinary system; musculoskeletal system; nervous system; and sensory organ. Used to study familial hypercholesterolemia and steatotic liver disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Ldlr Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC426418 | View Product |
| Stable overexpression | LC526418 | View Product | |
| AAV Vector & Virus | Long-term expression | VC426418 | View Product |
| Long-term expression | VC526418 | View Product | |
| Adenovirus | Transient expression | A426418 | View Product |
| Transient expression | A526418 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG426418 | View Product |
| Gene knockout (non-viral) | PG426418 | View Product | |
| Gene knockout (AAV) | VG426418 | View Product | |
| CRISPR Activation | Gene activation | LA426418 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS426418 | View Product |
| Gene knockdown (AAV) | VS426418 | View Product | |
| ORF Vector | Template DNA | PC426418 | View Product |
| Template DNA | PC526418 | View Product |
Rat Ldlr Gene Overview
| Gene Name | low density lipoprotein receptor |
|---|---|
| Gene Symbol | Ldlr |
| Synonyms | LDLRA |
| NCBI ID | 300438 |
| Ensembl ID | ENSRNOG00000009946 |
| Uniprot ID | P35952 |
| Gene Type | Protein coding |
Gene Summary
Enables low-density lipoprotein particle receptor activity. Involved in several processes, including cholesterol homeostasis; positive regulation of triglyceride catabolic process; and response to glucagon. Located in caveola and recycling endosome membrane. Used to study aortic atherosclerosis; atherosclerosis; familial hyperlipidemia; steatotic liver disease; and xanthomatosis. Biomarker of metabolic dysfunction and alcohol associated liver disease. Human ortholog(s) of this gene implicated in Alzheimer's disease; arteriosclerosis; familial hypercholesterolemia; hepatitis C; and migraine without aura. Orthologous to human LDLR (low density lipoprotein receptor). [provided by Alliance of Genome Resources, Jul 2025]
Rat Ldlr Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC626418 | View Product |
| AAV Vector & Virus | Long-term expression | VC626418 | View Product |
| Adenovirus | Transient expression | A626418 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG626418 | View Product |
| Gene knockout (non-viral) | PG626418 | View Product | |
| Gene knockout (AAV) | VG626418 | View Product | |
| CRISPR Activation | Gene activation | LA626418 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS626418 | View Product |
| Gene knockdown (AAV) | VS626418 | View Product | |
| ORF Vector | Template DNA | PC626418 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |