LGR5 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use LGR5-specific vectors and viral particles designed for reliable LGR5 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including LGR5 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human LGR5 Gene Overview
| Gene Name | leucine rich repeat containing G protein-coupled receptor 5 |
|---|---|
| Gene Symbol | LGR5 |
| Synonyms | FEX,HG38,GPR49,GPR67,GRP49 |
| NCBI ID | 8549 |
| Ensembl ID | ENSG00000139292 |
| Uniprot ID | O75473 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Human LGR5 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC126491 | View Product |
| AAV Vector & Virus | Long-term expression | VC126491 | View Product |
| Adenovirus | Transient expression | A126491 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG126491 | View Product |
| Gene knockout (non-viral) | PG126491 | View Product | |
| Gene knockout (AAV) | VG126491 | View Product | |
| CRISPR Activation | Gene activation | LA126491 | View Product |
| siRNA Tools | Gene knockdown (AAV) | VS126491 | View Product |
| ORF Vector | Template DNA | PC126491 | View Product |
Mouse Lgr5 Gene Overview
| Gene Name | leucine rich repeat containing G protein coupled receptor 5 |
|---|---|
| Gene Symbol | Lgr5 |
| Synonyms | FEX,Gpr49 |
| NCBI ID | 14160 |
| Ensembl ID | ENSMUSG00000020140 |
| Uniprot ID | Q9Z1P4 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a leucine-rich repeat-containing receptor (LGR) and member of the G protein-coupled, 7-transmembrane receptor (GPCR) superfamily. The encoded protein is a receptor for R-spondins and is involved in the canonical Wnt signaling pathway. This protein plays a role in the formation and maintenance of adult intestinal stem cells during postembryonic development. [provided by RefSeq, Sep 2015]
Mouse Lgr5 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC426491 | View Product |
| AAV Vector & Virus | Long-term expression | VC426491 | View Product |
| Adenovirus | Transient expression | A426491 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG426491 | View Product |
| Gene knockout (non-viral) | PG426491 | View Product | |
| Gene knockout (AAV) | VG426491 | View Product | |
| CRISPR Activation | Gene activation | LA426491 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS426491 | View Product |
| Gene knockdown (AAV) | VS426491 | View Product | |
| ORF Vector | Template DNA | PC426491 | View Product |
Rat Lgr5 Gene Overview
| Gene Name | leucine rich repeat containing G protein coupled receptor 5 |
|---|---|
| Gene Symbol | Lgr5 |
| Synonyms | Gpr49 |
| NCBI ID | 299802 |
| Ensembl ID | ENSRNOG00000004221 |
| Uniprot ID | D4AC13 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable transmembrane signaling receptor activity. Predicted to be involved in positive regulation of canonical Wnt signaling pathway. Predicted to act upstream of or within several processes, including epithelial cell proliferation involved in renal tubule morphogenesis; hair follicle development; and oocyte differentiation. Predicted to be located in trans-Golgi network membrane. Predicted to be active in plasma membrane. Orthologous to human LGR5 (leucine rich repeat containing G protein-coupled receptor 5). [provided by Alliance of Genome Resources, Jul 2025]
Rat Lgr5 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC626491 | View Product |
| AAV Vector & Virus | Long-term expression | VC626491 | View Product |
| Adenovirus | Transient expression | A626491 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG626491 | View Product |
| Gene knockout (non-viral) | PG626491 | View Product | |
| Gene knockout (AAV) | VG626491 | View Product | |
| CRISPR Activation | Gene activation | LA626491 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS626491 | View Product |
| Gene knockdown (AAV) | VS626491 | View Product | |
| ORF Vector | Template DNA | PC626491 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |