LRP1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use LRP1-specific vectors and viral particles designed for reliable LRP1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including LRP1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human LRP1 Gene Overview
| Gene Name | LDL receptor related protein 1 |
|---|---|
| Gene Symbol | LRP1 |
| Synonyms | APR,KPA,LRP,A2MR,CD91,DDH3,APOER,LRP1A,TGFBR5,IGFBP3R,IGFBP-3R,IGFBP3R1 |
| NCBI ID | 4035 |
| Ensembl ID | ENSG00000123384 |
| Uniprot ID | Q07954 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the low-density lipoprotein receptor family of proteins. The encoded preproprotein is proteolytically processed by furin to generate 515 kDa and 85 kDa subunits that form the mature receptor (PMID: 8546712). This receptor is involved in several cellular processes, including intracellular signaling, lipid homeostasis, and clearance of apoptotic cells. In addition, the encoded protein is necessary for the alpha 2-macroglobulin-mediated clearance of secreted amyloid precursor protein and beta-amyloid, the main component of amyloid plaques found in Alzheimer patients. Expression of this gene decreases with age and has been found to be lower than controls in brain tissue from Alzheimer's disease patients. [provided by RefSeq, Oct 2015]
Human LRP1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG127602 | View Product |
| Gene knockout (non-viral) | PG127602 | View Product | |
| Gene knockout (AAV) | VG127602 | View Product | |
| CRISPR Activation | Gene activation | LA127602 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS127602 | View Product |
| Gene knockdown (AAV) | VS127602 | View Product |
Mouse Lrp1 Gene Overview
| Gene Name | low density lipoprotein receptor-related protein 1 |
|---|---|
| Gene Symbol | Lrp1 |
| Synonyms | Lrp,A2mr,CD91,b2b1554Clo |
| NCBI ID | 16971 |
| Ensembl ID | ENSMUSG00000040249 |
| Uniprot ID | Q91ZX7 |
| Gene Type | Protein coding |
Gene Summary
Enables calcium ion binding activity; cargo receptor activity; and signaling receptor binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; negative regulation of signal transduction; and regulation of vesicle-mediated transport. Acts upstream of or within several processes, including endocytosis; heart development; and negative regulation of Wnt signaling pathway. Located in external side of plasma membrane. Is active in glutamatergic synapse and postsynaptic density membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and respiratory system. Used to study Alzheimer's disease; cardiomyopathy; congenital diaphragmatic hernia; gastroschisis; and omphalocele. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Lrp1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG427602 | View Product |
| Gene knockout (non-viral) | PG427602 | View Product | |
| Gene knockout (AAV) | VG427602 | View Product | |
| CRISPR Activation | Gene activation | LA427602 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS427602 | View Product |
| Gene knockdown (AAV) | VS427602 | View Product |
Rat Lrp1 Gene Overview
| Gene Name | LDL receptor related protein 1 |
|---|---|
| Gene Symbol | Lrp1 |
| Synonyms | LRP-1 |
| NCBI ID | 299858 |
| Ensembl ID | ENSRNOG00000025053 |
| Uniprot ID | G3V928 |
| Gene Type | Protein coding |
Gene Summary
Enables coreceptor activity; protease binding activity; and protein serine/threonine kinase binding activity. Involved in several processes, including positive regulation of cell migration; positive regulation of transport; and regulation of neuron projection development. Located in several cellular components, including axonal growth cone; cytoplasmic vesicle; and neuronal cell body. Used to study diabetes mellitus. Biomarker of Alzheimer's disease; prostate carcinoma in situ; and sciatic neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1). [provided by Alliance of Genome Resources, Apr 2025]
Rat Lrp1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG627602 | View Product |
| Gene knockout (non-viral) | PG627602 | View Product | |
| Gene knockout (AAV) | VG627602 | View Product | |
| CRISPR Activation | Gene activation | LA627602 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS627602 | View Product |
| Gene knockdown (AAV) | VS627602 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |