MAGEL2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use MAGEL2-specific vectors and viral particles designed for reliable MAGEL2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including MAGEL2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human MAGEL2 Gene Overview
| Gene Name | MAGE family member L2 |
|---|---|
| Gene Symbol | MAGEL2 |
| Synonyms | PWLS,nM15,NDNL1,SHFYNG |
| NCBI ID | 54551 |
| Ensembl ID | ENSG00000254585 |
| Uniprot ID | Q9UJ55 |
| Gene Type | Protein coding |
Gene Summary
Prader-Willi syndrome (PWS) is caused by the loss of expression of imprinted genes in chromosome 15q11-q13 region. Affected individuals exhibit neonatal hypotonia, developmental delay, and childhood-onset obesity. Necdin (NDN), a gene involved in the terminal differentiation of neurons, localizes to this region of the genome and has been implicated as one of the genes responsible for the etiology of PWS. This gene is structurally similar to NDN, is also localized to the PWS chromosomal region, and is paternally imprinted, suggesting a possible role for it in PWS. [provided by RefSeq, Oct 2010]
Human MAGEL2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC127948 | View Product |
| Adenovirus | Transient expression | A127948 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG127948 | View Product |
| Gene knockout (non-viral) | PG127948 | View Product | |
| Gene knockout (AAV) | VG127948 | View Product | |
| CRISPR Activation | Gene activation | LA127948 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS127948 | View Product |
| Gene knockdown (AAV) | VS127948 | View Product | |
| ORF Vector | Template DNA | PC127948 | View Product |
Mouse Magel2 Gene Overview
| Gene Name | MAGE family member L2 |
|---|---|
| Gene Symbol | Magel2 |
| Synonyms | ns7,nM15,NDNL1,Mage-l2 |
| NCBI ID | 27385 |
| Ensembl ID | ENSMUSG00000056972 |
| Uniprot ID | Q9QZ04 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable ubiquitin-protein transferase activity. Involved in negative regulation of DNA-templated transcription and regulation of circadian rhythm. Acts upstream of or within positive regulation of actin nucleation. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; egg cylinder; limb bud; pharynx; and reproductive system. Used to study Prader-Willi syndrome. Human ortholog(s) of this gene implicated in Schaaf-Yang syndrome. Orthologous to human MAGEL2 (MAGE family member L2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Magel2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC427948 | View Product |
| Adenovirus | Transient expression | A427948 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG427948 | View Product |
| Gene knockout (non-viral) | PG427948 | View Product | |
| Gene knockout (AAV) | VG427948 | View Product | |
| CRISPR Activation | Gene activation | LA427948 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS427948 | View Product |
| Gene knockdown (AAV) | VS427948 | View Product | |
| ORF Vector | Template DNA | PC427948 | View Product |
Rat Magel2 Gene Overview
| Gene Name | MAGE family member L2 |
|---|---|
| Gene Symbol | Magel2 |
| Synonyms | |
| NCBI ID | 679875 |
| Ensembl ID | ENSRNOG00000010158 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable ubiquitin-protein transferase activity. Predicted to be involved in several processes, including Arp2/3 complex-mediated actin nucleation; protein K63-linked ubiquitination; and retrograde transport, endosome to Golgi. Predicted to act upstream of or within positive regulation of actin nucleation. Predicted to be located in endosome. Predicted to be part of retromer complex. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in Schaaf-Yang syndrome. Orthologous to human MAGEL2 (MAGE family member L2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Magel2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |