MAP2K1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use MAP2K1-specific vectors and viral particles designed for reliable MAP2K1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including MAP2K1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human MAP2K1 Gene Overview
| Gene Name | mitogen-activated protein kinase kinase 1 |
|---|---|
| Gene Symbol | MAP2K1 |
| Synonyms | MEL,CFC3,MEK1,MKK1,MAPKK1,PRKMK1 |
| NCBI ID | 5604 |
| Ensembl ID | ENSG00000169032 |
| Uniprot ID | Q02750 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development. [provided by RefSeq, Jul 2008]
Human MAP2K1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| AAV Vector & Virus | Long-term expression | VC128012 | View Product |
| Adenovirus | Transient expression | A128012 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG128012 | View Product |
| Gene knockout (non-viral) | PG128012 | View Product | |
| Gene knockout (AAV) | VG128012 | View Product | |
| CRISPR Activation | Gene activation | LA128012 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS128012 | View Product |
| Gene knockdown (AAV) | VS128012 | View Product | |
| ORF Vector | Template DNA | PC128012 | View Product |
Mouse Map2k1 Gene Overview
| Gene Name | mitogen-activated protein kinase kinase 1 |
|---|---|
| Gene Symbol | Map2k1 |
| Synonyms | Mek1,MEKK1,MAPKK1,Prkmk1 |
| NCBI ID | 26395 |
| Ensembl ID | ENSMUSG00000004936 |
| Uniprot ID | P31938 |
| Gene Type | Protein coding |
Gene Summary
Enables MAP kinase kinase activity and protein serine/threonine kinase activity. Involved in MAPK cascade; cell surface receptor protein tyrosine kinase signaling pathway; and nervous system development. Acts upstream of with a positive effect on type B pancreatic cell proliferation. Acts upstream of or within several processes, including central nervous system development; regulation of neuron projection development; and respiratory system development. Predicted to be located in several cellular components, including dendrite cytoplasm; perikaryon; and perinuclear region of cytoplasm. Predicted to be active in glutamatergic synapse and postsynaptic density. Is expressed in several structures, including alimentary system; blastocyst; brain; genitourinary system; and sensory organ. Used to study cardiofaciocutaneous syndrome. Human ortholog(s) of this gene implicated in carcinoma (multiple); cardiofaciocutaneous syndrome 3; high grade glioma; and melorheostosis. Orthologous to human MAP2K1 (mitogen-activated protein kinase kinase 1). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Map2k1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC428012 | View Product |
| AAV Vector & Virus | Long-term expression | VC428012 | View Product |
| Adenovirus | Transient expression | A428012 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG428012 | View Product |
| Gene knockout (non-viral) | PG428012 | View Product | |
| Gene knockout (AAV) | VG428012 | View Product | |
| CRISPR Activation | Gene activation | LA428012 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS428012 | View Product |
| Gene knockdown (AAV) | VS428012 | View Product | |
| ORF Vector | Template DNA | PC428012 | View Product |
Rat Map2k3 Gene Overview
| Gene Name | mitogen activated protein kinase kinase 3 |
|---|---|
| Gene Symbol | Map2k3 |
| Synonyms | Mek3,Mkk3 |
| NCBI ID | 303200 |
| Ensembl ID | ENSRNOG00000065992 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable MAP kinase kinase activity and protein kinase binding activity. Involved in several processes, including cellular response to lipopolysaccharide; cellular response to sorbitol; and response to ischemia. Used to study retinal disease. Human ortholog(s) of this gene implicated in cervical cancer and restrictive cardiomyopathy. Orthologous to human MAP2K3 (mitogen-activated protein kinase kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Rat Map2k3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC628012 | View Product |
| AAV Vector & Virus | Long-term expression | VC628012 | View Product |
| Adenovirus | Transient expression | A628012 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG628012 | View Product |
| Gene knockout (non-viral) | PG628012 | View Product | |
| Gene knockout (AAV) | VG628012 | View Product | |
| CRISPR Activation | Gene activation | LA628012 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS628012 | View Product |
| Gene knockdown (AAV) | VS628012 | View Product | |
| ORF Vector | Template DNA | PC628012 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |