MAP2K3 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use MAP2K3-specific vectors and viral particles designed for reliable MAP2K3 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including MAP2K3 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human MAP2K3 Gene Overview
| Gene Name | mitogen-activated protein kinase kinase 3 |
|---|---|
| Gene Symbol | MAP2K3 |
| Synonyms | MEK3,MKK3,MAPKK3,PRKMK3,SAPKK2,SAPKK-2 |
| NCBI ID | 5606 |
| Ensembl ID | ENSG00000034152 |
| Uniprot ID | P46734 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene. [provided by RefSeq, Jul 2008]
Human MAP2K3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC128016 | View Product |
| AAV Vector & Virus | Long-term expression | VC128016 | View Product |
| Adenovirus | Transient expression | A128016 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG128016 | View Product |
| Gene knockout (non-viral) | PG128016 | View Product | |
| Gene knockout (AAV) | VG128016 | View Product | |
| CRISPR Activation | Gene activation | LA128016 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS128016 | View Product |
| Gene knockdown (AAV) | VS128016 | View Product | |
| ORF Vector | Template DNA | PC128016 | View Product |
Mouse Map2k3 Gene Overview
| Gene Name | mitogen-activated protein kinase kinase 3 |
|---|---|
| Gene Symbol | Map2k3 |
| Synonyms | MEK3,MKK3,MKK3b,Prkmk3,MAPKK 3 |
| NCBI ID | 26397 |
| Ensembl ID | ENSMUSG00000018932 |
| Uniprot ID | O09110 |
| Gene Type | Protein coding |
Gene Summary
Enables MAP kinase kinase activity and protein kinase binding activity. Acts upstream of or within several processes, including MAPK cascade; cardiac muscle contraction; and positive regulation of MAPK cascade. Is expressed in several structures, including alimentary system; brain; early conceptus; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in cervical cancer and restrictive cardiomyopathy. Orthologous to human MAP2K3 (mitogen-activated protein kinase kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Map2k3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC428016 | View Product |
| AAV Vector & Virus | Long-term expression | VC428016 | View Product |
| Adenovirus | Transient expression | A428016 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG428016 | View Product |
| Gene knockout (non-viral) | PG428016 | View Product | |
| Gene knockout (AAV) | VG428016 | View Product | |
| CRISPR Activation | Gene activation | LA428016 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS428016 | View Product |
| Gene knockdown (AAV) | VS428016 | View Product | |
| ORF Vector | Template DNA | PC428016 | View Product |
Rat Mapk1 Gene Overview
| Gene Name | mitogen activated protein kinase 1 |
|---|---|
| Gene Symbol | Mapk1 |
| Synonyms | ERT1,Erk2,ERK-2,p42-MAPK |
| NCBI ID | 116590 |
| Ensembl ID | ENSRNOG00000001849 |
| Uniprot ID | P63086 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including ATP binding activity; MAP kinase activity; and mitogen-activated protein kinase kinase kinase binding activity. Involved in several processes, including ERK1 and ERK2 cascade; cellular response to cAMP; and positive regulation of macromolecule biosynthetic process. Acts upstream of or within peptidyl-serine phosphorylation. Located in several cellular components, including caveola; dendrite cytoplasm; and perikaryon. Part of protein-containing complex. Is active in postsynaptic density. Used to study several diseases, including alcohol dependence; cocaine abuse; coronary artery disease (multiple); drug dependence (multiple); and gastric ulcer. Biomarker of alcohol use disorder; colon cancer; renal fibrosis; urethral obstruction; and vascular dementia. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 13; Parkinson's disease; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Mapk1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC628016 | View Product |
| AAV Vector & Virus | Long-term expression | VC628016 | View Product |
| Adenovirus | Transient expression | A628016 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG628016 | View Product |
| Gene knockout (non-viral) | PG628016 | View Product | |
| Gene knockout (AAV) | VG628016 | View Product | |
| CRISPR Activation | Gene activation | LA628016 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS628016 | View Product |
| Gene knockdown (AAV) | VS628016 | View Product | |
| ORF Vector | Template DNA | PC628016 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |