MAPK1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use MAPK1-specific vectors and viral particles designed for reliable MAPK1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including MAPK1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human MAPK1 Gene Overview
| Gene Name | mitogen-activated protein kinase 1 |
|---|---|
| Gene Symbol | MAPK1 |
| Synonyms | ERK,p38,p40,p41,ERK2,ERT1,NS13,ERK-2,MAPK2,PRKM1,PRKM2,P42MAPK,p41mapk,p42-MAPK |
| NCBI ID | 5594 |
| Ensembl ID | ENSG00000100030 |
| Uniprot ID | P28482 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the MAP kinase family. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. The activation of this kinase requires its phosphorylation by upstream kinases. Upon activation, this kinase translocates to the nucleus of the stimulated cells, where it phosphorylates nuclear targets. One study also suggests that this protein acts as a transcriptional repressor independent of its kinase activity. The encoded protein has been identified as a moonlighting protein based on its ability to perform mechanistically distinct functions. Two alternatively spliced transcript variants encoding the same protein, but differing in the UTRs, have been reported for this gene. [provided by RefSeq, Jan 2014]
Human MAPK1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| AAV Vector & Virus | Long-term expression | VC128052 | View Product |
| Adenovirus | Transient expression | A128052 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG128052 | View Product |
| Gene knockout (non-viral) | PG128052 | View Product | |
| Gene knockout (AAV) | VG128052 | View Product | |
| CRISPR Activation | Gene activation | LA128052 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS128052 | View Product |
| Gene knockdown (AAV) | VS128052 | View Product | |
| ORF Vector | Template DNA | PC128052 | View Product |
Mouse Mapk1 Gene Overview
| Gene Name | mitogen-activated protein kinase 1 |
|---|---|
| Gene Symbol | Mapk1 |
| Synonyms | ERK,Erk2,MAPK2,PRKM2,Prkm1,p41mapk,p42mapk,9030612K14Rik |
| NCBI ID | 26413 |
| Ensembl ID | ENSMUSG00000063358 |
| Uniprot ID | P63085 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including identical protein binding activity; phosphotyrosine residue binding activity; and protein serine/threonine kinase activity. Involved in several processes, including cell surface receptor protein tyrosine kinase signaling pathway; nervous system development; and protein phosphorylation. Acts upstream of or within several processes, including cell surface receptor signaling pathway; embryonic organ development; and respiratory system development. Located in several cellular components, including cytosol; mitochondrion; and pseudopodium. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; nervous system; and sensory organ. Used to study Weissenbacher-Zweymuller syndrome; autism spectrum disorder; and velocardiofacial syndrome. Human ortholog(s) of this gene implicated in several diseases, including Noonan syndrome 13; Parkinson's disease; adenocarcinoma (multiple); pulmonary hypertension; and renal cell carcinoma. Orthologous to human MAPK1 (mitogen-activated protein kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Mapk1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC428052 | View Product |
| Stable overexpression | LC528052 | View Product | |
| AAV Vector & Virus | Long-term expression | VC428052 | View Product |
| Long-term expression | VC528052 | View Product | |
| Adenovirus | Transient expression | A428052 | View Product |
| Transient expression | A528052 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG428052 | View Product |
| Gene knockout (non-viral) | PG428052 | View Product | |
| Gene knockout (AAV) | VG428052 | View Product | |
| CRISPR Activation | Gene activation | LA428052 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS428052 | View Product |
| Gene knockdown (AAV) | VS428052 | View Product | |
| ORF Vector | Template DNA | PC428052 | View Product |
| Template DNA | PC528052 | View Product |
Rat Mapk14 Gene Overview
| Gene Name | mitogen activated protein kinase 14 |
|---|---|
| Gene Symbol | Mapk14 |
| Synonyms | RK,Hog,p38,CRK1,CSBP,Exip,Mxi2,CSPB1,Csbp1,Csbp2,Prkm14,Prkm15,Sapk2A,p38Hog,p38alpha |
| NCBI ID | 81649 |
| Ensembl ID | ENSRNOG00000000513 |
| Uniprot ID | P70618 |
| Gene Type | Protein coding |
Gene Summary
Enables ATP binding activity and MAP kinase activity. Involved in several processes, including cellular response to transforming growth factor beta stimulus; protein autophosphorylation; and stress-activated MAPK cascade. Predicted to be located in mitochondrion; nuclear speck; and spindle pole. Predicted to be active in cytosol; glutamatergic synapse; and nucleus. Used to study diabetic neuropathy and osteoporosis. Biomarker of Alzheimer's disease; anti-basement membrane glomerulonephritis; and interstitial cystitis. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Apr 2025]
Rat Mapk14 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC628052 | View Product |
| AAV Vector & Virus | Long-term expression | VC628052 | View Product |
| Adenovirus | Transient expression | A628052 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG628052 | View Product |
| Gene knockout (non-viral) | PG628052 | View Product | |
| Gene knockout (AAV) | VG628052 | View Product | |
| CRISPR Activation | Gene activation | LA628052 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS628052 | View Product |
| Gene knockdown (AAV) | VS628052 | View Product | |
| ORF Vector | Template DNA | PC628052 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |