MAPK14 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use MAPK14-specific vectors and viral particles designed for reliable MAPK14 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including MAPK14 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human MAPK14 Gene Overview
| Gene Name | mitogen-activated protein kinase 14 |
|---|---|
| Gene Symbol | MAPK14 |
| Synonyms | RK,p38,CSBP,EXIP,Mxi2,CSBP1,CSBP2,CSPB1,PRKM14,PRKM15,SAPK2A,p38ALPHA |
| NCBI ID | 1432 |
| Ensembl ID | ENSG00000112062 |
| Uniprot ID | Q16539 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
Human MAPK14 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC128057 | View Product |
| AAV Vector & Virus | Long-term expression | VC128057 | View Product |
| Adenovirus | Transient expression | A128057 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG128057 | View Product |
| Gene knockout (non-viral) | PG128057 | View Product | |
| Gene knockout (AAV) | VG128057 | View Product | |
| CRISPR Activation | Gene activation | LA128057 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS128057 | View Product |
| Gene knockdown (AAV) | VS128057 | View Product | |
| ORF Vector | Template DNA | PC128057 | View Product |
Mouse Mapk14 Gene Overview
| Gene Name | mitogen-activated protein kinase 14 |
|---|---|
| Gene Symbol | Mapk14 |
| Synonyms | p38,Crk1,Mxi2,p38a,CSBP2,Csbp1,PRKM14,PRKM15,p38MAPK,p38alpha,p38-alpha |
| NCBI ID | 26416 |
| Ensembl ID | ENSMUSG00000053436 |
| Uniprot ID | P47811 |
| Gene Type | Protein coding |
Gene Summary
Enables MAP kinase activity and NFAT protein binding activity. Involved in several processes, including negative regulation of canonical Wnt signaling pathway; positive regulation of cell differentiation; and skeletal system development. Acts upstream of or within several processes, including cell surface receptor signaling pathway; positive regulation of cell differentiation; and positive regulation of macromolecule biosynthetic process. Located in mitochondrion; nucleus; and spindle pole. Is active in cytosol and glutamatergic synapse. Is expressed in several structures, including alimentary system; early conceptus; genitourinary system; head mesenchyme; and telencephalon. Human ortholog(s) of this gene implicated in colon cancer; colorectal carcinoma; nasopharynx carcinoma; and rectum cancer. Orthologous to human MAPK14 (mitogen-activated protein kinase 14). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Mapk14 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC428057 | View Product |
| Stable overexpression | LC528057 | View Product | |
| AAV Vector & Virus | Long-term expression | VC428057 | View Product |
| Long-term expression | VC528057 | View Product | |
| Adenovirus | Transient expression | A428057 | View Product |
| Transient expression | A528057 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG428057 | View Product |
| Gene knockout (non-viral) | PG428057 | View Product | |
| Gene knockout (AAV) | VG428057 | View Product | |
| CRISPR Activation | Gene activation | LA428057 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS428057 | View Product |
| Gene knockdown (AAV) | VS428057 | View Product | |
| ORF Vector | Template DNA | PC428057 | View Product |
| Template DNA | PC528057 | View Product |
Rat Mapk3 Gene Overview
| Gene Name | mitogen activated protein kinase 3 |
|---|---|
| Gene Symbol | Mapk3 |
| Synonyms | p44,ERK1,ERT2,MNK1,Erk-1,Esrk1,MAPK1,Prkm3,p44erk1,p44mapk |
| NCBI ID | 50689 |
| Ensembl ID | ENSRNOG00000053583 |
| Uniprot ID | P21708 |
| Gene Type | Protein coding |
Gene Summary
Enables ATP binding activity; MAP kinase activity; and scaffold protein binding activity. Involved in several processes, including arachidonate metabolic process; decidualization; and peptidyl-serine phosphorylation. Located in caveola; cytoplasm; and nucleoplasm. Part of protein-containing complex. Used to study several diseases, including alcohol dependence; cocaine abuse; drug dependence (multiple); gastric ulcer; and middle cerebral artery infarction. Biomarker of alcohol use disorder. Human ortholog(s) of this gene implicated in Parkinson's disease; carcinoma (multiple); and pulmonary hypertension. Orthologous to human MAPK3 (mitogen-activated protein kinase 3). [provided by Alliance of Genome Resources, Jul 2025]
Rat Mapk3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC628057 | View Product |
| AAV Vector & Virus | Long-term expression | VC628057 | View Product |
| Adenovirus | Transient expression | A628057 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG628057 | View Product |
| Gene knockout (non-viral) | PG628057 | View Product | |
| Gene knockout (AAV) | VG628057 | View Product | |
| CRISPR Activation | Gene activation | LA628057 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS628057 | View Product |
| Gene knockdown (AAV) | VS628057 | View Product | |
| ORF Vector | Template DNA | PC628057 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |