MAPK8 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use MAPK8-specific vectors and viral particles designed for reliable MAPK8 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including MAPK8 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human MAPK8 Gene Overview
| Gene Name | mitogen-activated protein kinase 8 |
|---|---|
| Gene Symbol | MAPK8 |
| Synonyms | JNK,JNK1,PRKM8,SAPK1,JNK-46,JNK1A2,SAPK1c,JNK21B1/2 |
| NCBI ID | 5599 |
| Ensembl ID | ENSG00000107643 |
| Uniprot ID | P45983 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Several alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Apr 2016]
Human MAPK8 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| siRNA Tools | Gene knockdown (AAV) | VS228071 | View Product |
Mouse Mapk8 Gene Overview
| Gene Name | mitogen-activated protein kinase 8 |
|---|---|
| Gene Symbol | Mapk8 |
| Synonyms | JNK,JNK1,Prkm8,SAPK1 |
| NCBI ID | 26419 |
| Ensembl ID | ENSMUSG00000021936 |
| Uniprot ID | Q91Y86 |
| Gene Type | Protein coding |
Gene Summary
Enables JUN kinase activity and protein serine/threonine/tyrosine kinase activity. Involved in several processes, including generation of neurons; integrin-mediated signaling pathway; and positive regulation of protein metabolic process. Acts upstream of or within several processes, including cellular response to nitric oxide; positive regulation of determination of dorsal identity; and protein phosphorylation. Located in several cellular components, including basal dendrite; mitochondrion; and podosome. Is active in Schaffer collateral - CA1 synapse and cytoplasm. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; sensory organ; and skin. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm; chronic mucocutaneous candidiasis; colorectal adenoma; rectal benign neoplasm; and type 2 diabetes mellitus. Orthologous to human MAPK8 (mitogen-activated protein kinase 8). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Mapk8 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC428071 | View Product |
| AAV Vector & Virus | Long-term expression | VC428071 | View Product |
| Adenovirus | Transient expression | A428071 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG428071 | View Product |
| Gene knockout (non-viral) | PG428071 | View Product | |
| Gene knockout (AAV) | VG428071 | View Product | |
| CRISPR Activation | Gene activation | LA428071 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS428071 | View Product |
| Gene knockdown (AAV) | VS428071 | View Product | |
| ORF Vector | Template DNA | PC428071 | View Product |
Rat Mapk8 Gene Overview
| Gene Name | mitogen-activated protein kinase 8 |
|---|---|
| Gene Symbol | Mapk8 |
| Synonyms | JNK |
| NCBI ID | 116554 |
| Ensembl ID | ENSRNOG00000020155 |
| Uniprot ID | P49185 |
| Gene Type | Protein coding |
Gene Summary
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. [provided by RefSeq, Jul 2012]
Rat Mapk8 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |