MCL1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use MCL1-specific vectors and viral particles designed for reliable MCL1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including MCL1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human MCL1 Gene Overview
| Gene Name | MCL1 apoptosis regulator, BCL2 family member |
|---|---|
| Gene Symbol | MCL1 |
| Synonyms | TM,EAT,MCL1L,MCL1S,Mcl-1,BCL2L3,MCL1-ES,bcl2-L-3,mcl1/EAT |
| NCBI ID | 4170 |
| Ensembl ID | ENSG00000143384 |
| Uniprot ID | Q07820 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing. [provided by RefSeq, Oct 2010]
Human MCL1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC128224 | View Product |
| AAV Vector & Virus | Long-term expression | VC128224 | View Product |
| Adenovirus | Transient expression | A128224 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG128224 | View Product |
| Gene knockout (non-viral) | PG128224 | View Product | |
| Gene knockout (AAV) | VG128224 | View Product | |
| CRISPR Activation | Gene activation | LA128224 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS128224 | View Product |
| Gene knockdown (AAV) | VS128224 | View Product | |
| ORF Vector | Template DNA | PC128224 | View Product |
Mouse Mcl1 Gene Overview
| Gene Name | myeloid cell leukemia sequence 1 |
|---|---|
| Gene Symbol | Mcl1 |
| Synonyms | Mcl-1,Gm52627 |
| NCBI ID | 17210 |
| Ensembl ID | ENSMUSG00000038612 |
| Uniprot ID | P97287 |
| Gene Type | Protein coding |
Gene Summary
Enables BH3 domain binding activity. Involved in extrinsic apoptotic signaling pathway in absence of ligand; negative regulation of apoptotic process; and positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway. Acts upstream of or within intrinsic apoptotic signaling pathway in response to DNA damage. Located in several cellular components, including cytosol; mitochondrion; and nucleus. Is expressed in several structures, including alimentary system; blastocyst; central nervous system; genitourinary system; and hemolymphoid system gland. Human ortholog(s) of this gene implicated in colorectal cancer; lung adenocarcinoma; lung cancer; and lung non-small cell carcinoma. Orthologous to human MCL1 (MCL1 apoptosis regulator, BCL2 family member). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Mcl1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC428224 | View Product |
| AAV Vector & Virus | Long-term expression | VC428224 | View Product |
| Adenovirus | Transient expression | A428224 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG428224 | View Product |
| Gene knockout (non-viral) | PG428224 | View Product | |
| Gene knockout (AAV) | VG428224 | View Product | |
| CRISPR Activation | Gene activation | LA428224 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS428224 | View Product |
| Gene knockdown (AAV) | VS428224 | View Product | |
| ORF Vector | Template DNA | PC428224 | View Product |
Rat Mcl1 Gene Overview
| Gene Name | MCL1 apoptosis regulator, BCL2 family member |
|---|---|
| Gene Symbol | Mcl1 |
| Synonyms | |
| NCBI ID | 60430 |
| Ensembl ID | ENSRNOG00000063678 |
| Uniprot ID | Q9Z1P3 |
| Gene Type | Protein coding |
Gene Summary
Enables BH domain binding activity and protein dimerization activity. Involved in negative regulation of apoptotic process. Predicted to be located in several cellular components, including cytosol; mitochondrion; and nucleus. Predicted to be part of Bcl-2 family protein complex. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in colorectal cancer; lung adenocarcinoma; lung cancer; and lung non-small cell carcinoma. Orthologous to human MCL1 (MCL1 apoptosis regulator, BCL2 family member). [provided by Alliance of Genome Resources, Jul 2025]
Rat Mcl1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC628224 | View Product |
| AAV Vector & Virus | Long-term expression | VC628224 | View Product |
| Adenovirus | Transient expression | A628224 | View Product |
| ORF Vector | Template DNA | PC628224 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |