MDM2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use MDM2-specific vectors and viral particles designed for reliable MDM2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including MDM2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human MDM2 Gene Overview
| Gene Name | MDM2 proto-oncogene |
|---|---|
| Gene Symbol | MDM2 |
| Synonyms | HDMX,LSKB,hdm2,ACTFS |
| NCBI ID | 4193 |
| Ensembl ID | ENSG00000135679 |
| Uniprot ID | Q00987 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
Human MDM2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC128269 | View Product |
| Adenovirus | Transient expression | A128269 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG128269 | View Product |
| Gene knockout (non-viral) | PG128269 | View Product | |
| Gene knockout (AAV) | VG128269 | View Product | |
| CRISPR Activation | Gene activation | LA128269 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS128269 | View Product |
| Gene knockdown (AAV) | VS128269 | View Product | |
| ORF Vector | Template DNA | PC128269 | View Product |
Mouse Mdm2 Gene Overview
| Gene Name | MDM2 proto-oncogene |
|---|---|
| Gene Symbol | Mdm2 |
| Synonyms | Mdm-2,1700007J15Rik |
| NCBI ID | 17246 |
| Ensembl ID | ENSMUSG00000020184 |
| Uniprot ID | P23804 |
| Gene Type | Protein coding |
Gene Summary
Enables p53 binding activity and ubiquitin protein ligase activity. Involved in apoptotic process and positive regulation of muscle cell differentiation. Acts upstream of or within several processes, including blood vessel remodeling; circulatory system development; and traversing start control point of mitotic cell cycle. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Mdm2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC428269 | View Product |
| AAV Vector & Virus | Long-term expression | VC428269 | View Product |
| Adenovirus | Transient expression | A428269 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG428269 | View Product |
| Gene knockout (non-viral) | PG428269 | View Product | |
| Gene knockout (AAV) | VG428269 | View Product | |
| CRISPR Activation | Gene activation | LA428269 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS428269 | View Product |
| Gene knockdown (AAV) | VS428269 | View Product | |
| ORF Vector | Template DNA | PC428269 | View Product |
Rat Mdm2 Gene Overview
| Gene Name | MDM2 proto-oncogene |
|---|---|
| Gene Symbol | Mdm2 |
| Synonyms | |
| NCBI ID | 314856 |
| Ensembl ID | ENSRNOG00000006304 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Enables p53 binding activity; signaling receptor binding activity; and ubiquitin protein ligase activity. Involved in several processes, including cellular response to UV-C; cellular response to estrogen stimulus; and regulation of macromolecule metabolic process. Is active in glutamatergic synapse and postsynaptic density. Used to study ichthyosis; post-traumatic stress disorder; and transient cerebral ischemia. Biomarker of breast cancer; intermittent claudication; liver disease; and priapism. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; glioblastoma; hepatocellular carcinoma; pancreatic ductal carcinoma; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene). [provided by Alliance of Genome Resources, Jul 2025]
Rat Mdm2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC628269 | View Product |
| AAV Vector & Virus | Long-term expression | VC628269 | View Product |
| Adenovirus | Transient expression | A628269 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG628269 | View Product |
| Gene knockout (non-viral) | PG628269 | View Product | |
| Gene knockout (AAV) | VG628269 | View Product | |
| CRISPR Activation | Gene activation | LA628269 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS628269 | View Product |
| Gene knockdown (AAV) | VS628269 | View Product | |
| ORF Vector | Template DNA | PC628269 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |