MET Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use MET-specific vectors and viral particles designed for reliable MET overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including MET CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human MET Gene Overview
| Gene Name | MET proto-oncogene, receptor tyrosine kinase |
|---|---|
| Gene Symbol | MET |
| Synonyms | DA11,HGFR,AUTS9,RCCP2,c-Met,DFNB97 |
| NCBI ID | 4233 |
| Ensembl ID | ENSG00000105976 |
| Uniprot ID | P08581 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the receptor tyrosine kinase family of proteins and the product of the proto-oncogene MET. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that are linked via disulfide bonds to form the mature receptor. Further processing of the beta subunit results in the formation of the M10 peptide, which has been shown to reduce lung fibrosis. Binding of its ligand, hepatocyte growth factor, induces dimerization and activation of the receptor, which plays a role in cellular survival, embryogenesis, and cellular migration and invasion. Mutations in this gene are associated with papillary renal cell carcinoma, hepatocellular carcinoma, and various head and neck cancers. Amplification and overexpression of this gene are also associated with multiple human cancers. [provided by RefSeq, May 2016]
Human MET Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC128379 | View Product |
| Adenovirus | Transient expression | A128379 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG128379 | View Product |
| Gene knockout (non-viral) | PG128379 | View Product | |
| Gene knockout (AAV) | VG128379 | View Product | |
| CRISPR Activation | Gene activation | LA128379 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS128379 | View Product |
| Gene knockdown (AAV) | VS128379 | View Product | |
| ORF Vector | Template DNA | PC128379 | View Product |
Mouse Met Gene Overview
| Gene Name | met proto-oncogene, receptor tyrosine kinase |
|---|---|
| Gene Symbol | Met |
| Synonyms | HGF,HGFR,Par4,c-Met |
| NCBI ID | 17295 |
| Ensembl ID | ENSMUSG00000009376 |
| Uniprot ID | P16056 |
| Gene Type | Protein coding |
Gene Summary
Enables hepatocyte growth factor receptor activity. Involved in cell surface receptor signaling pathway; modulation of chemical synaptic transmission; and positive chemotaxis. Acts upstream of or within several processes, including hepatocyte growth factor receptor signaling pathway; regulation of cytokine production; and striated muscle cell differentiation. Located in membrane. Is expressed in several structures, including alimentary system; branchial arch; central nervous system; genitourinary system; and limb. Used to study Gilles de la Tourette syndrome; autism spectrum disorder; breast cancer; and gestational diabetes. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); distal arthrogryposis; and multiple myeloma. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Met Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC428379 | View Product |
| Adenovirus | Transient expression | A428379 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG428379 | View Product |
| Gene knockout (non-viral) | PG428379 | View Product | |
| Gene knockout (AAV) | VG428379 | View Product | |
| CRISPR Activation | Gene activation | LA428379 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS428379 | View Product |
| Gene knockdown (AAV) | VS428379 | View Product | |
| ORF Vector | Template DNA | PC428379 | View Product |
Rat Met Gene Overview
| Gene Name | MET proto-oncogene, receptor tyrosine kinase |
|---|---|
| Gene Symbol | Met |
| Synonyms | Hgfr |
| NCBI ID | 24553 |
| Ensembl ID | ENSRNOG00000052745 |
| Uniprot ID | P97523 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including beta-catenin binding activity; hepatocyte growth factor receptor activity; and phospholipase binding activity. Involved in several processes, including neurogenesis; positive regulation of cellular component organization; and regulation of macromolecule metabolic process. Located in several cellular components, including excitatory synapse; postsynaptic membrane; and sperm flagellum. Biomarker of several diseases, including acute kidney failure; hepatobiliary system cancer (multiple); liver benign neoplasm; pancreatitis; and periodontitis. Human ortholog(s) of this gene implicated in autistic disorder; autosomal recessive nonsyndromic deafness 97; carcinoma (multiple); distal arthrogryposis; and multiple myeloma. Orthologous to human MET (MET proto-oncogene, receptor tyrosine kinase). [provided by Alliance of Genome Resources, Jul 2025]
Rat Met Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC628379 | View Product |
| Adenovirus | Transient expression | A628379 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG628379 | View Product |
| Gene knockout (non-viral) | PG628379 | View Product | |
| Gene knockout (AAV) | VG628379 | View Product | |
| CRISPR Activation | Gene activation | LA628379 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS628379 | View Product |
| Gene knockdown (AAV) | VS628379 | View Product | |
| ORF Vector | Template DNA | PC628379 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |