METTL3 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use METTL3-specific vectors and viral particles designed for reliable METTL3 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including METTL3 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human METTL3 Gene Overview
| Gene Name | methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit |
|---|---|
| Gene Symbol | METTL3 |
| Synonyms | M6A,IME4,Spo8,MT-A70,hMETTL3 |
| NCBI ID | 56339 |
| Ensembl ID | ENSG00000165819 |
| Uniprot ID | Q86U44 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes the 70 kDa subunit of MT-A which is part of N6-adenosine-methyltransferase. This enzyme is involved in the posttranscriptional methylation of internal adenosine residues in eukaryotic mRNAs, forming N6-methyladenosine. [provided by RefSeq, Jul 2008]
Human METTL3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC128416 | View Product |
| AAV Vector & Virus | Long-term expression | VC128416 | View Product |
| Adenovirus | Transient expression | A128416 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG128416 | View Product |
| Gene knockout (non-viral) | PG128416 | View Product | |
| Gene knockout (AAV) | VG128416 | View Product | |
| CRISPR Activation | Gene activation | LA128416 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS128416 | View Product |
| Gene knockdown (AAV) | VS128416 | View Product | |
| ORF Vector | Template DNA | PC128416 | View Product |
Mouse Mettl3 Gene Overview
| Gene Name | methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit |
|---|---|
| Gene Symbol | Mettl3 |
| Synonyms | M6A,Spo8,2310024F18Rik |
| NCBI ID | 56335 |
| Ensembl ID | ENSMUSG00000022160 |
| Uniprot ID | Q8C3P7 |
| Gene Type | Protein coding |
Gene Summary
Enables mRNA m(6)A methyltransferase activity. Involved in several processes, including RNA metabolic process; forebrain radial glial cell differentiation; and mRNA destabilization. Located in nucleus. Part of RNA N6-methyladenosine methyltransferase complex. Is expressed in brain; genitourinary system; hindlimb; intestine; and liver. Orthologous to human METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Mettl3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC428416 | View Product |
| AAV Vector & Virus | Long-term expression | VC428416 | View Product |
| Adenovirus | Transient expression | A428416 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG428416 | View Product |
| Gene knockout (non-viral) | PG428416 | View Product | |
| Gene knockout (AAV) | VG428416 | View Product | |
| CRISPR Activation | Gene activation | LA428416 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS428416 | View Product |
| Gene knockdown (AAV) | VS428416 | View Product | |
| ORF Vector | Template DNA | PC428416 | View Product |
Rat Mettl3 Gene Overview
| Gene Name | methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit |
|---|---|
| Gene Symbol | Mettl3 |
| Synonyms | |
| NCBI ID | 361035 |
| Ensembl ID | ENSRNOG00000013111 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including S-adenosyl-L-methionine binding activity; mRNA m(6)A methyltransferase activity; and protein heterodimerization activity. Predicted to be involved in several processes, including RNA metabolic process; negative regulation of type I interferon-mediated signaling pathway; and regulation of gene expression. Predicted to be located in Golgi apparatus; cytosol; and nuclear speck. Predicted to be part of RNA N6-methyladenosine methyltransferase complex. Predicted to be active in nucleus. Orthologous to human METTL3 (methyltransferase 3, N6-adenosine-methyltransferase complex catalytic subunit). [provided by Alliance of Genome Resources, Apr 2025]
Rat Mettl3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC628416 | View Product |
| AAV Vector & Virus | Long-term expression | VC628416 | View Product |
| Adenovirus | Transient expression | A628416 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG628416 | View Product |
| Gene knockout (non-viral) | PG628416 | View Product | |
| Gene knockout (AAV) | VG628416 | View Product | |
| CRISPR Activation | Gene activation | LA628416 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS628416 | View Product |
| Gene knockdown (AAV) | VS628416 | View Product | |
| ORF Vector | Template DNA | PC628416 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |