MFN2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use MFN2-specific vectors and viral particles designed for reliable MFN2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including MFN2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human MFN2 Gene Overview
| Gene Name | mitofusin 2 |
|---|---|
| Gene Symbol | MFN2 |
| Synonyms | HSG,MSL,MARF,CMT2A,CPRP1,CMT2A2,HMSN6A,CMT2A2A,CMT2A2B |
| NCBI ID | 9927 |
| Ensembl ID | ENSG00000116688 |
| Uniprot ID | O95140 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a mitochondrial membrane protein that participates in mitochondrial fusion and contributes to the maintenance and operation of the mitochondrial network. This protein is involved in the regulation of vascular smooth muscle cell proliferation, and it may play a role in the pathophysiology of obesity. Mutations in this gene cause Charcot-Marie-Tooth disease type 2A2, and hereditary motor and sensory neuropathy VI, which are both disorders of the peripheral nervous system. Defects in this gene have also been associated with early-onset stroke. Two transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
Human MFN2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC128446 | View Product |
| AAV Vector & Virus | Long-term expression | VC128446 | View Product |
| Adenovirus | Transient expression | A128446 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG128446 | View Product |
| Gene knockout (non-viral) | PG128446 | View Product | |
| Gene knockout (AAV) | VG128446 | View Product | |
| CRISPR Activation | Gene activation | LA128446 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS128446 | View Product |
| Gene knockdown (AAV) | VS128446 | View Product | |
| ORF Vector | Template DNA | PC128446 | View Product |
Mouse Mfn2 Gene Overview
| Gene Name | mitofusin 2 |
|---|---|
| Gene Symbol | Mfn2 |
| Synonyms | Fzo,D630023P19Rik |
| NCBI ID | 170731 |
| Ensembl ID | ENSMUSG00000029020 |
| Uniprot ID | Q80U63 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including GTP binding activity; enzyme binding activity; and identical protein binding activity. Involved in mitochondrial fusion; positive regulation of cold-induced thermogenesis; and type 2 mitophagy. Acts upstream of or within blastocyst formation and camera-type eye morphogenesis. Located in microtubule cytoskeleton and mitochondrion. Is expressed in several structures, including early conceptus; eye; heart; oocyte; and tibialis anterior. Used to study Charcot-Marie-Tooth disease type 2A2A. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; Charcot-Marie-Tooth disease type 6; and multiple symmetric lipomatosis. Orthologous to human MFN2 (mitofusin 2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Mfn2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC428446 | View Product |
| AAV Vector & Virus | Long-term expression | VC428446 | View Product |
| Adenovirus | Transient expression | A428446 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG428446 | View Product |
| Gene knockout (non-viral) | PG428446 | View Product | |
| Gene knockout (AAV) | VG428446 | View Product | |
| CRISPR Activation | Gene activation | LA428446 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS428446 | View Product |
| Gene knockdown (AAV) | VS428446 | View Product | |
| ORF Vector | Template DNA | PC428446 | View Product |
Rat Mfn2 Gene Overview
| Gene Name | mitofusin 2 |
|---|---|
| Gene Symbol | Mfn2 |
| Synonyms | HSG |
| NCBI ID | 64476 |
| Ensembl ID | ENSRNOG00000046424 |
| Uniprot ID | Q8R500 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including GTP binding activity; identical protein binding activity; and small GTPase binding activity. Involved in several processes, including negative regulation of organelle organization; positive regulation of steroid hormone secretion; and regulation of reactive oxygen species biosynthetic process. Located in cytosol and mitochondrial outer membrane. Used to study carotid stenosis. Biomarker of several diseases, including artery disease (multiple); obesity; prediabetes syndrome; steatotic liver disease (multiple); and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease; Charcot-Marie-Tooth disease type 2A2A; Charcot-Marie-Tooth disease type 2A2B; Charcot-Marie-Tooth disease type 6; and multiple symmetric lipomatosis. Orthologous to human MFN2 (mitofusin 2). [provided by Alliance of Genome Resources, Apr 2025]
Rat Mfn2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC628446 | View Product |
| AAV Vector & Virus | Long-term expression | VC628446 | View Product |
| Adenovirus | Transient expression | A628446 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG628446 | View Product |
| Gene knockout (non-viral) | PG628446 | View Product | |
| Gene knockout (AAV) | VG628446 | View Product | |
| CRISPR Activation | Gene activation | LA628446 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS628446 | View Product |
| Gene knockdown (AAV) | VS628446 | View Product | |
| ORF Vector | Template DNA | PC628446 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |