MLKL Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use MLKL-specific vectors and viral particles designed for reliable MLKL overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including MLKL CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human MLKL Gene Overview
| Gene Name | mixed lineage kinase domain like pseudokinase |
|---|---|
| Gene Symbol | MLKL |
| Synonyms | hMLKL |
| NCBI ID | 197259 |
| Ensembl ID | ENSG00000168404 |
| Uniprot ID | Q8NB16 |
| Gene Type | Protein coding |
Gene Summary
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]
Human MLKL Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC130196 | View Product |
| AAV Vector & Virus | Long-term expression | VC130196 | View Product |
| Adenovirus | Transient expression | A130196 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG130196 | View Product |
| Gene knockout (non-viral) | PG130196 | View Product | |
| Gene knockout (AAV) | VG130196 | View Product | |
| CRISPR Activation | Gene activation | LA130196 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS130196 | View Product |
| Gene knockdown (AAV) | VS130196 | View Product | |
| ORF Vector | Template DNA | PC130196 | View Product |
Mouse Mlkl Gene Overview
| Gene Name | mixed lineage kinase domain-like |
|---|---|
| Gene Symbol | Mlkl |
| Synonyms | 9130019I15Rik |
| NCBI ID | 74568 |
| Ensembl ID | ENSMUSG00000012519 |
| Uniprot ID | Q9D2Y4 |
| Gene Type | Protein coding |
Gene Summary
This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to lack protein kinase activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (Rip3), which is a key signaling molecule in necroptosis pathway. Knockout of this gene in mice showed that it is essential for necroptosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2015]
Mouse Mlkl Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC430196 | View Product |
| AAV Vector & Virus | Long-term expression | VC430196 | View Product |
| Adenovirus | Transient expression | A430196 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG430196 | View Product |
| Gene knockout (non-viral) | PG430196 | View Product | |
| Gene knockout (AAV) | VG430196 | View Product | |
| CRISPR Activation | Gene activation | LA430196 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS430196 | View Product |
| Gene knockdown (AAV) | VS430196 | View Product | |
| ORF Vector | Template DNA | PC430196 | View Product |
Rat Mlkl Gene Overview
| Gene Name | mixed lineage kinase domain like pseudokinase |
|---|---|
| Gene Symbol | Mlkl |
| Synonyms | |
| NCBI ID | 690743 |
| Ensembl ID | ENSRNOG00000042353 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable ATP binding activity; identical protein binding activity; and protein kinase binding activity. Predicted to be involved in defense response to virus; necroptotic process; and protein homotrimerization. Predicted to be located in several cellular components, including cell junction; cytosol; and nucleus. Predicted to be active in cytoplasm. Orthologous to human MLKL (mixed lineage kinase domain like pseudokinase). [provided by Alliance of Genome Resources, Jul 2025]
Rat Mlkl Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |