NF2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use NF2-specific vectors and viral particles designed for reliable NF2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including NF2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human NF2 Gene Overview
| Gene Name | NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor |
|---|---|
| Gene Symbol | NF2 |
| Synonyms | ACN,SCH,BANF,SWNV,merlin-1 |
| NCBI ID | 4771 |
| Ensembl ID | ENSG00000186575 |
| Uniprot ID | P35240 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a protein that is similar to some members of the ERM (ezrin, radixin, moesin) family of proteins that link cytoskeletal components with proteins in the cell membrane. The encoded protein is involved in regulation of contact-dependent inhibition of cell proliferation and functions in cell-cell adhesion and transmembrane signaling. The encoded protein has been shown to interact with cell-surface proteins, proteins involved in cytoskeletal dynamics, and proteins involved in regulating ion transport. Disruption of this protein's function has been implicated in tumorigenesis and metastasis. Mutations in this gene are associated with neurofibromatosis type II which is characterized by nervous system and skin tumors and ocular abnormalities. [provided by RefSeq, May 2022]
Human NF2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC231757 | View Product |
| Stable overexpression | LC331757 | View Product | |
| AAV Vector & Virus | Long-term expression | VC131757 | View Product |
| Long-term expression | VC231757 | View Product | |
| Adenovirus | Transient expression | A131757 | View Product |
| Transient expression | A231757 | View Product | |
| Transient expression | A331757 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG131757 | View Product |
| Gene knockout (non-viral) | PG131757 | View Product | |
| Gene knockout (AAV) | VG131757 | View Product | |
| CRISPR Activation | Gene activation | LA131757 | View Product |
| siRNA Tools | Gene knockdown (AAV) | VS131757 | View Product |
| ORF Vector | Template DNA | PC131757 | View Product |
| Template DNA | PC231757 | View Product |
Mouse Neurog3 Gene Overview
| Gene Name | neurogenin 3 |
|---|---|
| Gene Symbol | Neurog3 |
| Synonyms | ngn3,Atoh5,Math4B,bHLHa7 |
| NCBI ID | 11925 |
| Ensembl ID | ENSMUSG00000044312 |
| Uniprot ID | P70661 |
| Gene Type | Protein coding |
Gene Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin DNA binding activity. Involved in positive regulation of DNA-templated transcription and transdifferentiation. Acts upstream of or within epithelial cell differentiation; positive regulation of transcription by RNA polymerase II; and regulation of dendrite morphogenesis. Located in nucleus. Is expressed in several structures, including central nervous system; early conceptus; eye; genitourinary system; and gut. Human ortholog(s) of this gene implicated in congenital malabsorptive diarrhea 4; glucose intolerance; and type 2 diabetes mellitus. Orthologous to human NEUROG3 (neurogenin 3). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Neurog3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC431757 | View Product |
| Stable overexpression | LC531757 | View Product | |
| AAV Vector & Virus | Long-term expression | VC431757 | View Product |
| Long-term expression | VC531757 | View Product | |
| Adenovirus | Transient expression | A431757 | View Product |
| Transient expression | A531757 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG431757 | View Product |
| Gene knockout (non-viral) | PG431757 | View Product | |
| Gene knockout (AAV) | VG431757 | View Product | |
| CRISPR Activation | Gene activation | LA431757 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS431757 | View Product |
| Gene knockdown (AAV) | VS431757 | View Product | |
| ORF Vector | Template DNA | PC431757 | View Product |
| Template DNA | PC531757 | View Product |
Rat Nf2 Gene Overview
| Gene Name | NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor |
|---|---|
| Gene Symbol | Nf2 |
| Synonyms | merlin |
| NCBI ID | 25744 |
| Ensembl ID | ENSRNOG00000007948 |
| Uniprot ID | Q63648 |
| Gene Type | Protein coding |
Gene Summary
Enables beta-catenin binding activity; integrin binding activity; and protein domain specific binding activity. Involved in negative regulation of cell growth. Located in perinuclear region of cytoplasm. Part of protein-containing complex. Biomarker of epilepsy. Human ortholog(s) of this gene implicated in gastrointestinal system cancer (multiple); malignant pleural mesothelioma; meningioma (multiple); neurilemmoma; and vestibular schwannomatosis. Orthologous to human NF2 (NF2, moesin-ezrin-radixin like (MERLIN) tumor suppressor). [provided by Alliance of Genome Resources, Jul 2025]
Rat Nf2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC631757 | View Product |
| AAV Vector & Virus | Long-term expression | VC631757 | View Product |
| Adenovirus | Transient expression | A631757 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG631757 | View Product |
| Gene knockout (non-viral) | PG631757 | View Product | |
| Gene knockout (AAV) | VG631757 | View Product | |
| CRISPR Activation | Gene activation | LA631757 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS631757 | View Product |
| Gene knockdown (AAV) | VS631757 | View Product | |
| ORF Vector | Template DNA | PC631757 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |