NFE2L2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use NFE2L2-specific vectors and viral particles designed for reliable NFE2L2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including NFE2L2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human NFE2L2 Gene Overview
| Gene Name | NFE2 like bZIP transcription factor 2 |
|---|---|
| Gene Symbol | NFE2L2 |
| Synonyms | NRF2,Nrf-2,IMDDHH |
| NCBI ID | 4780 |
| Ensembl ID | ENSG00000116044 |
| Uniprot ID | Q16236 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a transcription factor which is a member of a small family of basic leucine zipper (bZIP) proteins. The encoded transcription factor regulates genes which contain antioxidant response elements (ARE) in their promoters; many of these genes encode proteins involved in response to injury and inflammation which includes the production of free radicals. Multiple transcript variants encoding different isoforms have been characterized for this gene. [provided by RefSeq, Sep 2015]
Human NFE2L2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC131768 | View Product |
| AAV Vector & Virus | Long-term expression | VC131768 | View Product |
| Adenovirus | Transient expression | A131768 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG131768 | View Product |
| Gene knockout (non-viral) | PG131768 | View Product | |
| Gene knockout (AAV) | VG131768 | View Product | |
| CRISPR Activation | Gene activation | LA131768 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS131768 | View Product |
| Gene knockdown (AAV) | VS131768 | View Product | |
| ORF Vector | Template DNA | PC131768 | View Product |
Mouse Nfe2 Gene Overview
| Gene Name | nuclear factor, erythroid derived 2 |
|---|---|
| Gene Symbol | Nfe2 |
| Synonyms | p45,NF-E2,p45NFE2,p45nf-e2,NF-E2/P45 |
| NCBI ID | 18022 |
| Ensembl ID | ENSMUSG00000058794 |
| Uniprot ID | Q07279 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; WW domain binding activity; and identical protein binding activity. Acts upstream of or within several processes, including labyrinthine layer blood vessel development; negative regulation of bone mineralization; and positive regulation of peptidyl-lysine acetylation. Located in nucleus. Is expressed in several structures, including bone marrow; eye; genitourinary system; limb; and yolk sac. Orthologous to human NFE2 (nuclear factor, erythroid 2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Nfe2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC431768 | View Product |
| AAV Vector & Virus | Long-term expression | VC431768 | View Product |
| Adenovirus | Transient expression | A431768 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG431768 | View Product |
| Gene knockout (non-viral) | PG431768 | View Product | |
| Gene knockout (AAV) | VG431768 | View Product | |
| CRISPR Activation | Gene activation | LA431768 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS431768 | View Product |
| Gene knockdown (AAV) | VS431768 | View Product | |
| ORF Vector | Template DNA | PC431768 | View Product |
Rat Nfe2l2 Gene Overview
| Gene Name | NFE2 like bZIP transcription factor 2 |
|---|---|
| Gene Symbol | Nfe2l2 |
| Synonyms | |
| NCBI ID | 83619 |
| Ensembl ID | ENSRNOG00000001548 |
| Uniprot ID | O54968 |
| Gene Type | Protein coding |
Gene Summary
Enables transcription cis-regulatory region binding activity and transcription coregulator binding activity. Involved in several processes, including aflatoxin catabolic process; positive regulation of macromolecule biosynthetic process; and regulation of cell migration. Located in nucleus. Used to study diabetic retinopathy; liver disease (multiple); middle cerebral artery infarction; myocardial infarction; and pulmonary fibrosis. Biomarker of several diseases, including extrahepatic cholestasis; kidney failure (multiple); metabolic dysfunction-associated steatohepatitis; neurodegenerative disease (multiple); and traumatic brain injury. Human ortholog(s) of this gene implicated in Alzheimer's disease; cataract; hepatocellular carcinoma; macular degeneration; and tuberculosis. Orthologous to human NFE2L2 (NFE2 like bZIP transcription factor 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Nfe2l2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC631768 | View Product |
| AAV Vector & Virus | Long-term expression | VC631768 | View Product |
| Adenovirus | Transient expression | A631768 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG631768 | View Product |
| Gene knockout (non-viral) | PG631768 | View Product | |
| Gene knockout (AAV) | VG631768 | View Product | |
| CRISPR Activation | Gene activation | LA631768 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS631768 | View Product |
| Gene knockdown (AAV) | VS631768 | View Product | |
| ORF Vector | Template DNA | PC631768 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |