NLRP3 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use NLRP3-specific vectors and viral particles designed for reliable NLRP3 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including NLRP3 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human NLRP3 Gene Overview
| Gene Name | NLR family pyrin domain containing 3 |
|---|---|
| Gene Symbol | NLRP3 |
| Synonyms | AII,AVP,FCU,MWS,FCAS,KEFH,CIAS1,FCAS1,NALP3,C1orf7,CLR1.1,DFNA34,PYPAF1,AGTAVPRL |
| NCBI ID | 114548 |
| Ensembl ID | ENSG00000162711 |
| Uniprot ID | Q96P20 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a pyrin-like protein containing a pyrin domain, a nucleotide-binding site (NBS) domain, and a leucine-rich repeat (LRR) motif. This protein interacts with the apoptosis-associated speck-like protein PYCARD/ASC, which contains a caspase recruitment domain, and is a member of the NLRP3 inflammasome complex. This complex functions as an upstream activator of NF-kappaB signaling, and it plays a role in the regulation of inflammation, the immune response, and apoptosis. The SARS-CoV 3a protein, a transmembrane pore-forming viroporin, has been shown to activate the NLRP3 inflammasome via the formation of ion channels in macrophages. Mutations in this gene are associated with familial cold autoinflammatory syndrome (FCAS), Muckle-Wells syndrome (MWS), chronic infantile neurological cutaneous and articular (CINCA) syndrome, neonatal-onset multisystem inflammatory disease (NOMID), keratoendotheliitis fugax hereditarian, and deafness, autosomal dominant 34, with or without inflammation. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Alternative 5' UTR structures are suggested by available data; however, insufficient evidence is available to determine if all of the represented 5' UTR splice patterns are biologically valid. [provided by RefSeq, Aug 2020]
Human NLRP3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC131916 | View Product |
| AAV Vector & Virus | Long-term expression | VC131916 | View Product |
| Adenovirus | Transient expression | A131916 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG131916 | View Product |
| Gene knockout (non-viral) | PG131916 | View Product | |
| Gene knockout (AAV) | VG131916 | View Product | |
| CRISPR Activation | Gene activation | LA131916 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS131916 | View Product |
| Gene knockdown (AAV) | VS131916 | View Product | |
| ORF Vector | Template DNA | PC131916 | View Product |
Mouse Nlrp3 Gene Overview
| Gene Name | NLR family, pyrin domain containing 3 |
|---|---|
| Gene Symbol | Nlrp3 |
| Synonyms | FCU,MWS,FCAS,Cias1,Mmig1,NALP3,Pypaf1,AII/AVP,AGTAVPRL |
| NCBI ID | 216799 |
| Ensembl ID | ENSMUSG00000032691 |
| Uniprot ID | Q8R4B8 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including ATP hydrolysis activity; phosphatidylinositol-4-phosphate binding activity; and signaling adaptor activity. Involved in several processes, including positive regulation of immune response; positive regulation of macromolecule biosynthetic process; and response to bacterium. Acts upstream of or within acute inflammatory response; defense response to virus; and regulation of inflammatory response. Located in interphase microtubule organizing center; mitochondrion; and nucleus. Part of NLRP3 inflammasome complex. Is active in membrane. Is expressed in central nervous system and retina. Used to study CINCA Syndrome; familial cold autoinflammatory syndrome 1; and metabolic dysfunction-associated steatotic liver disease. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Nlrp3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC431916 | View Product |
| AAV Vector & Virus | Long-term expression | VC431916 | View Product |
| Adenovirus | Transient expression | A431916 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG431916 | View Product |
| Gene knockout (non-viral) | PG431916 | View Product | |
| Gene knockout (AAV) | VG431916 | View Product | |
| CRISPR Activation | Gene activation | LA431916 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS431916 | View Product |
| Gene knockdown (AAV) | VS431916 | View Product | |
| ORF Vector | Template DNA | PC431916 | View Product |
Rat Nlrp3 Gene Overview
| Gene Name | NLR family, pyrin domain containing 3 |
|---|---|
| Gene Symbol | Nlrp3 |
| Synonyms | Cias1 |
| NCBI ID | 287362 |
| Ensembl ID | ENSRNOG00000003170 |
| Uniprot ID | D4A523 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable several functions, including ATP hydrolysis activity; adenyl ribonucleotide binding activity; and cysteine-type endopeptidase activator activity. Involved in response to ethanol. Predicted to be located in several cellular components, including Golgi membrane; interphase microtubule organizing center; and mitochondrion. Predicted to be part of NLRP3 inflammasome complex. Predicted to be active in cytosol and membrane. Biomarker of alcoholic hepatitis and myocardial infarction. Human ortholog(s) of this gene implicated in CINCA Syndrome; Muckle-Wells syndrome; autosomal dominant nonsyndromic deafness 34; familial cold autoinflammatory syndrome 1; and urticaria. Orthologous to human NLRP3 (NLR family pyrin domain containing 3). [provided by Alliance of Genome Resources, Jul 2025]
Rat Nlrp3 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC631916 | View Product |
| AAV Vector & Virus | Long-term expression | VC631916 | View Product |
| Adenovirus | Transient expression | A631916 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG631916 | View Product |
| Gene knockout (non-viral) | PG631916 | View Product | |
| Gene knockout (AAV) | VG631916 | View Product | |
| CRISPR Activation | Gene activation | LA631916 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS631916 | View Product |
| Gene knockdown (AAV) | VS631916 | View Product | |
| ORF Vector | Template DNA | PC631916 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |