NOD2 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use NOD2-specific vectors and viral particles designed for reliable NOD2 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including NOD2 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human NOD2 Gene Overview
| Gene Name | nucleotide binding oligomerization domain containing 2 |
|---|---|
| Gene Symbol | NOD2 |
| Synonyms | CD,ACUG,BLAU,IBD1,YAOS,BLAUS,NLRC2,NOD2B,CARD15,CLR16.3,PSORAS1 |
| NCBI ID | 64127 |
| Ensembl ID | ENSG00000167207 |
| Uniprot ID | Q9HC29 |
| Gene Type | Protein coding |
Gene Summary
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2014]
Human NOD2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC131976 | View Product |
| AAV Vector & Virus | Long-term expression | VC131976 | View Product |
| Adenovirus | Transient expression | A231976 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG131976 | View Product |
| Gene knockout (non-viral) | PG131976 | View Product | |
| Gene knockout (AAV) | VG131976 | View Product | |
| CRISPR Activation | Gene activation | LA131976 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS131976 | View Product |
| Gene knockdown (AAV) | VS131976 | View Product | |
| ORF Vector | Template DNA | PC131976 | View Product |
Mouse Nod2 Gene Overview
| Gene Name | nucleotide-binding oligomerization domain containing 2 |
|---|---|
| Gene Symbol | Nod2 |
| Synonyms | CD,ACUG,BLAU,IBD1,Nlrc2,Card15,F830032C23Rik |
| NCBI ID | 257632 |
| Ensembl ID | ENSMUSG00000055994 |
| Uniprot ID | Q8K3Z0 |
| Gene Type | Protein coding |
Gene Summary
Enables muramyl dipeptide binding activity and pattern recognition receptor activity. Involved in several processes, including host-mediated regulation of intestinal microbiota composition; positive regulation of metabolic process; and positive regulation of signal transduction. Acts upstream of or within several processes, including positive regulation of MAPK cascade; regulation of gene expression; and response to bacterium. Predicted to be located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and phagocytic vesicle. Predicted to be part of protein-containing complex. Predicted to be active in cytosol. Predicted to be extrinsic component of plasma membrane. Used to study inflammatory bowel disease 1. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); familial Mediterranean fever; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Nod2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC431976 | View Product |
| AAV Vector & Virus | Long-term expression | VC431976 | View Product |
| Adenovirus | Transient expression | A431976 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG431976 | View Product |
| Gene knockout (non-viral) | PG431976 | View Product | |
| Gene knockout (AAV) | VG431976 | View Product | |
| CRISPR Activation | Gene activation | LA431976 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS431976 | View Product |
| Gene knockdown (AAV) | VS431976 | View Product | |
| ORF Vector | Template DNA | PC431976 | View Product |
Rat Nod2 Gene Overview
| Gene Name | nucleotide-binding oligomerization domain containing 2 |
|---|---|
| Gene Symbol | Nod2 |
| Synonyms | Card15 |
| NCBI ID | 291912 |
| Ensembl ID | ENSRNOG00000014124 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Enables muramyl dipeptide binding activity. Involved in several processes, including cellular response to peptidoglycan; positive regulation of dendritic cell cytokine production; and response to muramyl dipeptide. Predicted to be located in several cellular components, including Golgi apparatus; basolateral plasma membrane; and phagocytic vesicle. Predicted to be part of protein-containing complex. Predicted to be active in cytosol and plasma membrane. Predicted to be extrinsic component of plasma membrane. Biomarker of colitis; middle cerebral artery infarction; and pancreatitis. Human ortholog(s) of this gene implicated in several diseases, including Blau syndrome; autoimmune disease (multiple); familial Mediterranean fever; intestinal disease (multiple); and lung disease (multiple). Orthologous to human NOD2 (nucleotide binding oligomerization domain containing 2). [provided by Alliance of Genome Resources, Jul 2025]
Rat Nod2 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC631976 | View Product |
| AAV Vector & Virus | Long-term expression | VC631976 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG631976 | View Product |
| Gene knockout (non-viral) | PG631976 | View Product | |
| Gene knockout (AAV) | VG631976 | View Product | |
| CRISPR Activation | Gene activation | LA631976 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS631976 | View Product |
| Gene knockdown (AAV) | VS631976 | View Product | |
| ORF Vector | Template DNA | PC631976 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |