NOTCH1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use NOTCH1-specific vectors and viral particles designed for reliable NOTCH1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including NOTCH1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human NOTCH1 Gene Overview
| Gene Name | notch receptor 1 |
|---|---|
| Gene Symbol | NOTCH1 |
| Synonyms | hN1,AOS5,TAN1,AOVD1 |
| NCBI ID | 4851 |
| Ensembl ID | ENSG00000148400 |
| Uniprot ID | P46531 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the NOTCH family of proteins. Members of this Type I transmembrane protein family share structural characteristics including an extracellular domain consisting of multiple epidermal growth factor-like (EGF) repeats, and an intracellular domain consisting of multiple different domain types. Notch signaling is an evolutionarily conserved intercellular signaling pathway that regulates interactions between physically adjacent cells through binding of Notch family receptors to their cognate ligands. The encoded preproprotein is proteolytically processed in the trans-Golgi network to generate two polypeptide chains that heterodimerize to form the mature cell-surface receptor. This receptor plays a role in the development of numerous cell and tissue types. Mutations in this gene are associated with aortic valve disease, Adams-Oliver syndrome, T-cell acute lymphoblastic leukemia, chronic lymphocytic leukemia, and head and neck squamous cell carcinoma. [provided by RefSeq, Jan 2016]
Human NOTCH1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG132013 | View Product |
| Gene knockout (non-viral) | PG132013 | View Product | |
| Gene knockout (AAV) | VG132013 | View Product | |
| CRISPR Activation | Gene activation | LA132013 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS132013 | View Product |
| Gene knockdown (AAV) | VS132013 | View Product | |
| ORF Vector | Template DNA | PC132013 | View Product |
Mouse Notch1 Gene Overview
| Gene Name | notch 1 |
|---|---|
| Gene Symbol | Notch1 |
| Synonyms | N1,Mis6,Tan1,lin-12,9930111A19Rik |
| NCBI ID | 18128 |
| Ensembl ID | ENSMUSG00000026923 |
| Uniprot ID | Q01705 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including Notch binding activity; transcription coactivator activity; and transcription regulator activator activity. Involved in several processes, including circulatory system development; negative regulation of cell differentiation; and regulation of signal transduction. Acts upstream of or within several processes, including circulatory system development; epithelial cell differentiation; and regulation of epithelial cell differentiation. Located in several cellular components, including adherens junction; apical plasma membrane; and cell surface. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia/lymphoma; aortic valve disease 1; and congenital heart disease. Orthologous to human NOTCH1 (notch receptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Notch1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG432013 | View Product |
| Gene knockout (non-viral) | PG432013 | View Product | |
| Gene knockout (AAV) | VG432013 | View Product | |
| CRISPR Activation | Gene activation | LA432013 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS432013 | View Product |
| Gene knockdown (AAV) | VS432013 | View Product | |
| ORF Vector | Template DNA | PC432013 | View Product |
Rat Notch1 Gene Overview
| Gene Name | notch receptor 1 |
|---|---|
| Gene Symbol | Notch1 |
| Synonyms | TAN1,NOTCH |
| NCBI ID | 25496 |
| Ensembl ID | ENSRNOG00000019322 |
| Uniprot ID | Q07008 |
| Gene Type | Protein coding |
Gene Summary
Enables transmembrane signaling receptor activity. Involved in several processes, including central nervous system development; positive regulation of cell differentiation; and regulation of biosynthetic process. Located in acrosomal vesicle; nucleus; and plasma membrane. Biomarker of lung carcinoma (multiple); pulmonary fibrosis; retinopathy of prematurity; and transient cerebral ischemia. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia/lymphoma; aortic valve disease 1; and congenital heart disease. Orthologous to human NOTCH1 (notch receptor 1). [provided by Alliance of Genome Resources, Apr 2025]
Rat Notch1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG632013 | View Product |
| Gene knockout (non-viral) | PG632013 | View Product | |
| Gene knockout (AAV) | VG632013 | View Product | |
| CRISPR Activation | Gene activation | LA632013 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS632013 | View Product |
| Gene knockdown (AAV) | VS632013 | View Product | |
| ORF Vector | Template DNA | PC632013 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |