NOX4 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use NOX4-specific vectors and viral particles designed for reliable NOX4 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including NOX4 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human NOX4 Gene Overview
| Gene Name | NADPH oxidase 4 |
|---|---|
| Gene Symbol | NOX4 |
| Synonyms | KOX,KOX-1,RENOX |
| NCBI ID | 50507 |
| Ensembl ID | ENSG00000086991 |
| Uniprot ID | Q9NPH5 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a member of the NOX-family of enzymes that functions as the catalytic subunit the NADPH oxidase complex. The encoded protein is localized to non-phagocytic cells where it acts as an oxygen sensor and catalyzes the reduction of molecular oxygen to various reactive oxygen species (ROS). The ROS generated by this protein have been implicated in numerous biological functions including signal transduction, cell differentiation and tumor cell growth. A pseudogene has been identified on the other arm of chromosome 11. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
Human NOX4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC132026 | View Product |
| AAV Vector & Virus | Long-term expression | VC132026 | View Product |
| Adenovirus | Transient expression | A132026 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG132026 | View Product |
| Gene knockout (non-viral) | PG132026 | View Product | |
| Gene knockout (AAV) | VG132026 | View Product | |
| CRISPR Activation | Gene activation | LA132026 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS132026 | View Product |
| Gene knockdown (AAV) | VS132026 | View Product | |
| ORF Vector | Template DNA | PC132026 | View Product |
Mouse Nox4 Gene Overview
| Gene Name | NADPH oxidase 4 |
|---|---|
| Gene Symbol | Nox4 |
| Synonyms | |
| NCBI ID | 50490 |
| Ensembl ID | ENSMUSG00000030562 |
| Uniprot ID | Q9JHI8 |
| Gene Type | Protein coding |
Gene Summary
Enables protein tyrosine kinase binding activity and superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of macromolecule metabolic process; and superoxide anion generation. Acts upstream of or within bone resorption and cardiac muscle cell differentiation. Located in cell periphery; mitochondrion; and perinuclear region of cytoplasm. Is expressed in embryo; heart; metanephros; renal cortex; and ventricle compact myocardium. Orthologous to human NOX4 (NADPH oxidase 4). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Nox4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC432026 | View Product |
| AAV Vector & Virus | Long-term expression | VC432026 | View Product |
| Adenovirus | Transient expression | A432026 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG432026 | View Product |
| Gene knockout (non-viral) | PG432026 | View Product | |
| Gene knockout (AAV) | VG432026 | View Product | |
| CRISPR Activation | Gene activation | LA432026 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS432026 | View Product |
| Gene knockdown (AAV) | VS432026 | View Product | |
| ORF Vector | Template DNA | PC432026 | View Product |
Rat Nox4 Gene Overview
| Gene Name | NADPH oxidase 4 |
|---|---|
| Gene Symbol | Nox4 |
| Synonyms | |
| NCBI ID | 85431 |
| Ensembl ID | ENSRNOG00000013925 |
| Uniprot ID | Q924V1 |
| Gene Type | Protein coding |
Gene Summary
Enables NAD(P)H oxidase H2O2-forming activity and superoxide-generating NAD(P)H oxidase activity. Involved in several processes, including cellular response to cAMP; cellular response to gamma radiation; and cellular response to mercury ion. Located in several cellular components, including endoplasmic reticulum; focal adhesion; and stress fiber. Part of NADPH oxidase complex. Used to study hypertension. Biomarker of hypertension; metabolic dysfunction-associated steatohepatitis; obesity; and steatotic liver disease. Orthologous to human NOX4 (NADPH oxidase 4). [provided by Alliance of Genome Resources, Jul 2025]
Rat Nox4 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC632026 | View Product |
| AAV Vector & Virus | Long-term expression | VC632026 | View Product |
| Adenovirus | Transient expression | A632026 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG632026 | View Product |
| Gene knockout (non-viral) | PG632026 | View Product | |
| Gene knockout (AAV) | VG632026 | View Product | |
| CRISPR Activation | Gene activation | LA632026 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS632026 | View Product |
| Gene knockdown (AAV) | VS632026 | View Product | |
| ORF Vector | Template DNA | PC632026 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |