NPC1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use NPC1-specific vectors and viral particles designed for reliable NPC1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including NPC1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human NPC1 Gene Overview
| Gene Name | NPC intracellular cholesterol transporter 1 |
|---|---|
| Gene Symbol | NPC1 |
| Synonyms | NPC,POGZ,SLC65A1 |
| NCBI ID | 4864 |
| Ensembl ID | ENSG00000141458 |
| Uniprot ID | O15118 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a large protein that resides in the limiting membrane of endosomes and lysosomes and mediates intracellular cholesterol trafficking via binding of cholesterol to its N-terminal domain. It is predicted to have a cytoplasmic C-terminus, 13 transmembrane domains, and 3 large loops in the lumen of the endosome - the last loop being at the N-terminus. This protein transports low-density lipoproteins to late endosomal/lysosomal compartments where they are hydrolized and released as free cholesterol. Defects in this gene cause Niemann-Pick type C disease, a rare autosomal recessive neurodegenerative disorder characterized by over accumulation of cholesterol and glycosphingolipids in late endosomal/lysosomal compartments.[provided by RefSeq, Aug 2009]
Human NPC1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC132044 | View Product |
| Adenovirus | Transient expression | A132044 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG132044 | View Product |
| Gene knockout (non-viral) | PG132044 | View Product | |
| Gene knockout (AAV) | VG132044 | View Product | |
| CRISPR Activation | Gene activation | LA132044 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS132044 | View Product |
| Gene knockdown (AAV) | VS132044 | View Product | |
| ORF Vector | Template DNA | PC132044 | View Product |
Mouse Npc1 Gene Overview
| Gene Name | NPC intracellular cholesterol transporter 1 |
|---|---|
| Gene Symbol | Npc1 |
| Synonyms | spm,lcsd,nmf164,D18Ertd139e,D18Ertd723e,A430089E03Rik |
| NCBI ID | 18145 |
| Ensembl ID | ENSMUSG00000024413 |
| Uniprot ID | O35604 |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable cholesterol binding activity. Involved in several processes, including cholesterol homeostasis; protein glycosylation; and symbiont entry into host cell. Acts upstream of or within several processes, including adult walking behavior; cholesterol efflux; and cyclodextrin metabolic process. Located in several cellular components, including lysosome; membrane raft; and nuclear envelope. Is expressed in several structures, including genitourinary system; liver; lung; spleen; and stomach. Used to study Niemann-Pick disease and Niemann-Pick disease type C1. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C1. Orthologous to human NPC1 (NPC intracellular cholesterol transporter 1). [provided by Alliance of Genome Resources, Apr 2025]
Mouse Npc1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC432044 | View Product |
| Adenovirus | Transient expression | A432044 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG432044 | View Product |
| Gene knockout (non-viral) | PG432044 | View Product | |
| Gene knockout (AAV) | VG432044 | View Product | |
| CRISPR Activation | Gene activation | LA432044 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS432044 | View Product |
| Gene knockdown (AAV) | VS432044 | View Product | |
| ORF Vector | Template DNA | PC432044 | View Product |
Rat Npc1 Gene Overview
| Gene Name | NPC intracellular cholesterol transporter 1 |
|---|---|
| Gene Symbol | Npc1 |
| Synonyms | Cdig2,SLC66A1 |
| NCBI ID | 266732 |
| Ensembl ID | ENSRNOG00000012016 |
| Uniprot ID | |
| Gene Type | Protein coding |
Gene Summary
Predicted to enable cholesterol binding activity and cholesterol transfer activity. Involved in negative regulation of epithelial cell apoptotic process and response to cadmium ion. Predicted to be located in several cellular components, including bounding membrane of organelle; membrane raft; and perinuclear region of cytoplasm. Predicted to be active in lysosome and plasma membrane. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C1. Orthologous to human NPC1 (NPC intracellular cholesterol transporter 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Npc1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |