NR3C1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use NR3C1-specific vectors and viral particles designed for reliable NR3C1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including NR3C1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human NR3C1 Gene Overview
| Gene Name | nuclear receptor subfamily 3 group C member 1 |
|---|---|
| Gene Symbol | NR3C1 |
| Synonyms | GR,GCR,GRL,GCCR,GCRST |
| NCBI ID | 2908 |
| Ensembl ID | ENSG00000113580 |
| Uniprot ID | P04150 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]
Human NR3C1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC132138 | View Product |
| AAV Vector & Virus | Long-term expression | VC132138 | View Product |
| Adenovirus | Transient expression | A132138 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG132138 | View Product |
| Gene knockout (non-viral) | PG132138 | View Product | |
| Gene knockout (AAV) | VG132138 | View Product | |
| CRISPR Activation | Gene activation | LA132138 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS132138 | View Product |
| Gene knockdown (AAV) | VS132138 | View Product | |
| ORF Vector | Template DNA | PC132138 | View Product |
Mouse Nr3c1 Gene Overview
| Gene Name | nuclear receptor subfamily 3, group C, member 1 |
|---|---|
| Gene Symbol | Nr3c1 |
| Synonyms | GR,Grl1,Grl-1 |
| NCBI ID | 14815 |
| Ensembl ID | ENSMUSG00000024431 |
| Uniprot ID | P06537 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including identical protein binding activity; nuclear glucocorticoid receptor activity; and promoter-specific chromatin binding activity. Involved in several processes, including glial cell differentiation; nuclear receptor-mediated glucocorticoid signaling pathway; and positive regulation of miRNA transcription. Acts upstream of or within several processes, including maternal behavior; regulation of primary metabolic process; and response to cortisol. Located in cytosol; membrane; and nucleus. Is expressed in several structures, including alimentary system; central nervous system; eye; genitourinary system; and leg muscle. Used to study primary hyperaldosteronism. Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; anorexia nervosa; cocaine abuse; heroin dependence; and lung disease (multiple). Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Nr3c1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC432138 | View Product |
| AAV Vector & Virus | Long-term expression | VC432138 | View Product |
| Adenovirus | Transient expression | A432138 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG432138 | View Product |
| Gene knockout (non-viral) | PG432138 | View Product | |
| Gene knockout (AAV) | VG432138 | View Product | |
| CRISPR Activation | Gene activation | LA432138 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS432138 | View Product |
| Gene knockdown (AAV) | VS432138 | View Product | |
| ORF Vector | Template DNA | PC432138 | View Product |
Rat Nr3c1 Gene Overview
| Gene Name | nuclear receptor subfamily 3, group C, member 1 |
|---|---|
| Gene Symbol | Nr3c1 |
| Synonyms | GR,Gcr,Grl |
| NCBI ID | 24413 |
| Ensembl ID | ENSRNOG00000014096 |
| Uniprot ID | P06536 |
| Gene Type | Protein coding |
Gene Summary
Enables several functions, including heat shock protein binding activity; receptor tyrosine kinase binding activity; and transcription coactivator activity. Involved in several processes, including positive regulation of macromolecule biosynthetic process; regulation of synaptic plasticity; and response to glucocorticoid. Located in several cellular components, including chromatin; cytosol; and dendritic spine. Part of protein-containing complex. Is active in glutamatergic synapse and postsynaptic density, intracellular component. Used to study several diseases, including alcohol dependence; alcohol use disorder; alcoholic neuropathy; cocaine abuse; and morphine dependence. Biomarker of several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; brain disease (multiple); cocaine dependence; and cognitive disorder (multiple). Human ortholog(s) of this gene implicated in several diseases, including alcohol dependence; anorexia nervosa; heroin dependence; lung disease (multiple); and nicotine dependence. Orthologous to human NR3C1 (nuclear receptor subfamily 3 group C member 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Nr3c1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC632138 | View Product |
| AAV Vector & Virus | Long-term expression | VC632138 | View Product |
| Adenovirus | Transient expression | A632138 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG632138 | View Product |
| Gene knockout (non-viral) | PG632138 | View Product | |
| Gene knockout (AAV) | VG632138 | View Product | |
| CRISPR Activation | Gene activation | LA632138 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS632138 | View Product |
| Gene knockdown (AAV) | VS632138 | View Product | |
| ORF Vector | Template DNA | PC632138 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |