NRP1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use NRP1-specific vectors and viral particles designed for reliable NRP1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including NRP1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human NRP1 Gene Overview
| Gene Name | neuropilin 1 |
|---|---|
| Gene Symbol | NRP1 |
| Synonyms | NP1,NRP,BDCA4,CD304,VEGF165R |
| NCBI ID | 8829 |
| Ensembl ID | ENSG00000099250 |
| Uniprot ID | O14786 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes one of two neuropilins, which contain specific protein domains which allow them to participate in several different types of signaling pathways that control cell migration. Neuropilins contain a large N-terminal extracellular domain, made up of complement-binding, coagulation factor V/VIII, and meprin domains. These proteins also contains a short membrane-spanning domain and a small cytoplasmic domain. Neuropilins bind many ligands and various types of co-receptors; they affect cell survival, migration, and attraction. Some of the ligands and co-receptors bound by neuropilins are vascular endothelial growth factor (VEGF) and semaphorin family members. This protein has also been determined to act as a co-receptor for SARS-CoV-2 (which causes COVID-19) to infect host cells. [provided by RefSeq, Nov 2020]
Human NRP1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC132179 | View Product |
| AAV Vector & Virus | Long-term expression | VC132179 | View Product |
| Adenovirus | Transient expression | A132179 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG132179 | View Product |
| Gene knockout (non-viral) | PG132179 | View Product | |
| Gene knockout (AAV) | VG132179 | View Product | |
| CRISPR Activation | Gene activation | LA132179 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS132179 | View Product |
| Gene knockdown (AAV) | VS132179 | View Product | |
| ORF Vector | Template DNA | PC132179 | View Product |
Mouse Nrp1 Gene Overview
| Gene Name | neuropilin 1 |
|---|---|
| Gene Symbol | Nrp1 |
| Synonyms | Nrp,NP-1,Npn1,NPN-1,C530029I03 |
| NCBI ID | 18186 |
| Ensembl ID | ENSMUSG00000025810 |
| Uniprot ID | P97333 |
| Gene Type | Protein coding |
Gene Summary
Enables protein kinase binding activity; transmembrane signaling receptor activity; and vascular endothelial growth factor binding activity. Involved in several processes, including cell surface receptor signaling pathway; nervous system development; and vasculature development. Acts upstream of or within several processes, including circulatory system development; dichotomous subdivision of terminal units involved in salivary gland branching; and nervous system development. Located in several cellular components, including endosome; focal adhesion; and neurofilament. Is active in glutamatergic synapse and postsynaptic membrane. Is expressed in several structures, including cardiovascular system; jaw; lung; nervous system; and sensory organ. Used to study retinal vein occlusion. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and tetralogy of Fallot. Orthologous to human NRP1 (neuropilin 1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Nrp1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC432179 | View Product |
| AAV Vector & Virus | Long-term expression | VC432179 | View Product |
| Adenovirus | Transient expression | A432179 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG432179 | View Product |
| Gene knockout (non-viral) | PG432179 | View Product | |
| Gene knockout (AAV) | VG432179 | View Product | |
| CRISPR Activation | Gene activation | LA432179 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS432179 | View Product |
| Gene knockdown (AAV) | VS432179 | View Product | |
| ORF Vector | Template DNA | PC432179 | View Product |
Rat Nrp1 Gene Overview
| Gene Name | neuropilin 1 |
|---|---|
| Gene Symbol | Nrp1 |
| Synonyms | Nrp |
| NCBI ID | 246331 |
| Ensembl ID | ENSRNOG00000010744 |
| Uniprot ID | Q9QWJ9 |
| Gene Type | Protein coding |
Gene Summary
Enables semaphorin receptor activity. Involved in several processes, including negative regulation of axon extension involved in axon guidance; positive regulation of platelet-derived growth factor receptor signaling pathway; and positive regulation of smooth muscle cell migration. Located in cell surface; growth cone; and neuronal cell body. Biomarker of transient cerebral ischemia. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma and tetralogy of Fallot. Orthologous to human NRP1 (neuropilin 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Nrp1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC632179 | View Product |
| AAV Vector & Virus | Long-term expression | VC632179 | View Product |
| Adenovirus | Transient expression | A632179 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG632179 | View Product |
| Gene knockout (non-viral) | PG632179 | View Product | |
| Gene knockout (AAV) | VG632179 | View Product | |
| CRISPR Activation | Gene activation | LA632179 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS632179 | View Product |
| Gene knockdown (AAV) | VS632179 | View Product | |
| ORF Vector | Template DNA | PC632179 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |