PAK1 Expression Vectors, Lentivirus & CRISPR Knockout Vectors
Enhance your research with ready-to-use PAK1-specific vectors and viral particles designed for reliable PAK1 overexpression, knockout, and silencing across a wide range of experimental systems. abm offers a complete portfolio of validated molecular tools – including PAK1 CRISPR knockout vectors, lentiviral particles, AAV vectors, adenovirus, ORF clones, and siRNA constructs for both in vitro and in vivo applications.
Human PAK1 Gene Overview
| Gene Name | p21 (RAC1) activated kinase 1 |
|---|---|
| Gene Symbol | PAK1 |
| Synonyms | IDDMSSD,p65-PAK,PAKalpha,alpha-PAK |
| NCBI ID | 5058 |
| Ensembl ID | ENSG00000149269 |
| Uniprot ID | Q13153 |
| Gene Type | Protein coding |
Gene Summary
This gene encodes a family member of serine/threonine p21-activating kinases, known as PAK proteins. These proteins are critical effectors that link RhoGTPases to cytoskeleton reorganization and nuclear signaling, and they serve as targets for the small GTP binding proteins Cdc42 and Rac. This specific family member regulates cell motility and morphology. Mutations in this gene have been associated with macrocephaly, seizures, and speech delay. Overexpression of this gene is also reported in many cancer types, and particularly in breast cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2020]
Human PAK1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC135958 | View Product |
| AAV Vector & Virus | Long-term expression | VC135958 | View Product |
| Adenovirus | Transient expression | A135958 | View Product |
| Transient expression | A235958 | View Product | |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG135958 | View Product |
| Gene knockout (non-viral) | PG135958 | View Product | |
| Gene knockout (AAV) | VG135958 | View Product | |
| CRISPR Activation | Gene activation | LA135958 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS135958 | View Product |
| Gene knockdown (AAV) | VS135958 | View Product | |
| ORF Vector | Template DNA | PC135958 | View Product |
Mouse Pak1 Gene Overview
| Gene Name | p21 (RAC1) activated kinase 1 |
|---|---|
| Gene Symbol | Pak1 |
| Synonyms | Paka,PAK-1 |
| NCBI ID | 18479 |
| Ensembl ID | ENSMUSG00000030774 |
| Uniprot ID | O88643 |
| Gene Type | Protein coding |
Gene Summary
Enables protein serine/threonine kinase activity. Involved in regulation of trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Acts upstream of or within several processes, including nervous system development; neurotransmitter secretion; and observational learning. Located in several cellular components, including dendrite; growth cone; and nucleus. Is active in GABA-ergic synapse; glutamatergic synapse; and postsynaptic density. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Mouse Pak1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC435958 | View Product |
| AAV Vector & Virus | Long-term expression | VC435958 | View Product |
| Adenovirus | Transient expression | A435958 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG435958 | View Product |
| Gene knockout (non-viral) | PG435958 | View Product | |
| Gene knockout (AAV) | VG435958 | View Product | |
| CRISPR Activation | Gene activation | LA435958 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS435958 | View Product |
| Gene knockdown (AAV) | VS435958 | View Product | |
| ORF Vector | Template DNA | PC435958 | View Product |
Rat Pak1 Gene Overview
| Gene Name | p21 (RAC1) activated kinase 1 |
|---|---|
| Gene Symbol | Pak1 |
| Synonyms | |
| NCBI ID | 29431 |
| Ensembl ID | ENSRNOG00000029784 |
| Uniprot ID | P35465 |
| Gene Type | Protein coding |
Gene Summary
Enables protein kinase binding activity and protein serine/threonine kinase activity. Involved in several processes, including nervous system development; positive regulation of cell migration; and regulation of cell growth. Located in several cellular components, including Z disc; intercalated disc; and ruffle. Biomarker of brain ischemia. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and schizophrenia. Orthologous to human PAK1 (p21 (RAC1) activated kinase 1). [provided by Alliance of Genome Resources, Jul 2025]
Rat Pak1 Related Products
| Product Type | Key Applications | Cat. No. | Product |
|---|---|---|---|
| Lentiviral Vector & Virus | Stable overexpression | LC635958 | View Product |
| AAV Vector & Virus | Long-term expression | VC635958 | View Product |
| Adenovirus | Transient expression | A635958 | View Product |
| CRISPR KO Tools | Gene knockout (Lentiviral) | LG635958 | View Product |
| Gene knockout (non-viral) | PG635958 | View Product | |
| Gene knockout (AAV) | VG635958 | View Product | |
| CRISPR Activation | Gene activation | LA635958 | View Product |
| siRNA Tools | Gene knockdown (Lentiviral) | LS635958 | View Product |
| Gene knockdown (AAV) | VS635958 | View Product | |
| ORF Vector | Template DNA | PC635958 | View Product |
Accelerate Discovery with Research-Ready Constructs
| Why Researchers Choose abm | Workflow Benefits |
|---|---|
| Gene-Specific Constructs | Eliminate time-consuming cloning and accelerate project timelines |
| Available as Plasmid DNA or Packaged Virus | Choose delivery format that best fits your experiment |
| Validated Sequence Design | Ensure reliable, reproducible experimental performance |
| Available in Multiple Species Options | Simplify cross-species and translational research studies |
| Flexible Customization Services | Tailor constructs with different promoters, tags, markers and other modifications |
| Expert Technical Support | Get guidance from gene delivery specialists |
Product Overview & Key Features
| System | Applications | Key Features |
|---|---|---|
| CRISPR Knockout Vectors & Viruses | Targeted gene disruption & functional knockout studies | •Pre-designed validated sgRNAs •Available in All-in-One Cas9 + sgRNA or sgRNA-only formats •Available as lentivirus, AAV and non-viral •Ideal for stable genome editing |
| Lentiviral Expression Vectors & Particles | Stable gene overexpression or delivery into difficult-to-transfect cells | •Long-term expression through genomic integration •Highly efficient in dividing and non-dividing cells •Ideal for stable cell line generation |
| AAV Vectors & Packaged Virus | In vivo delivery & transient expression with low immunogenicity | •Multiple serotypes available for tissue targeting •Excellent for animal studies and sensitive primary cells •Episomal expression with strong safety profile |
| Adenovirus | High-efficiency transient expression | •Rapid, robust gene expression •Large cargo capacity •Ideal for primary cells and strong short-term expression studies |
| ORF Vector | Template for coding sequence | •Ready-to-use full-length coding sequences •Low cost and convenient alternative to gene synthesis |
| siRNA Knockdown Tools | Temporary gene silencing & pathway validation | •Robust gene knockdown •Ideal for target validation and preliminary functional screening •Available as Lentivirus, AAV or synthetic dsRNA oligos |